Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a.

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Bibliographic Details
Title: Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a.
Authors: Burbidge O; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK., Pastok MW; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, NE2 4HH Newcastle upon Tyne, UK., Papini D; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, NE2 4HH Newcastle upon Tyne, UK., Hodder SL; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK., Zenkevičiūtė G; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK., Tan KZJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, NE2 4HH Newcastle upon Tyne, UK., Turberville S; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, NE2 4HH Newcastle upon Tyne, UK., Noble MEM; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, NE2 4HH Newcastle upon Tyne, UK., Endicott JA; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, NE2 4HH Newcastle upon Tyne, UK. Electronic address: jane.endicott@ncl.ac.uk., Itzhaki L; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK. Electronic address: lsi10@cam.ac.uk.
Source: Structure (London, England : 1993) [Structure] 2025 Nov 06; Vol. 33 (11), pp. 1984-1997.e12. Date of Electronic Publication: 2025 Aug 14.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1878-4186
DOI:10.1016/j.str.2025.07.017