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Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF.

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Title: Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF.
Authors: Gibb AA; Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute, Department of Medicine, University of Louisville, Louisville, Kentucky, USA; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., LaPenna K; Cardiovascular Center for Excellence, Department of Pharmacology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Gaspar RB; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Latchman NR; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Tan Y; Fox Chase Cancer Center, Temple University, Philadelphia, Pennsylvania, USA., Choya-Foces C; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Doiron JE; Cardiovascular Center for Excellence, Department of Pharmacology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Li Z; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Xia H; Cardiovascular Center for Excellence, Department of Pharmacology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Lazaropoulos MP; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Conwell M; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Sharp TE 3rd; Department of Molecular Pharmacology and Physiology, University of South Florida Health, Tampa, Florida, USA., Goodchild TT; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Lefer DJ; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: david.lefer@cshs.org., Elrod JW; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA. Electronic address: elrod@temple.edu.
Source: JACC. Basic to translational science [JACC Basic Transl Sci] 2025 Sep; Vol. 10 (9), pp. 101334. Date of Electronic Publication: 2025 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF.
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  Data: <searchLink fieldCode="AU" term="%22Gibb+AA%22">Gibb AA</searchLink>; Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute, Department of Medicine, University of Louisville, Louisville, Kentucky, USA; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22LaPenna+K%22">LaPenna K</searchLink>; Cardiovascular Center for Excellence, Department of Pharmacology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Gaspar+RB%22">Gaspar RB</searchLink>; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Latchman+NR%22">Latchman NR</searchLink>; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; Fox Chase Cancer Center, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Choya-Foces+C%22">Choya-Foces C</searchLink>; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Doiron+JE%22">Doiron JE</searchLink>; Cardiovascular Center for Excellence, Department of Pharmacology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Xia+H%22">Xia H</searchLink>; Cardiovascular Center for Excellence, Department of Pharmacology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Lazaropoulos+MP%22">Lazaropoulos MP</searchLink>; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Conwell+M%22">Conwell M</searchLink>; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+TE+3rd%22">Sharp TE 3rd</searchLink>; Department of Molecular Pharmacology and Physiology, University of South Florida Health, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Goodchild+TT%22">Goodchild TT</searchLink>; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Lefer+DJ%22">Lefer DJ</searchLink>; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: david.lefer@cshs.org.<br /><searchLink fieldCode="AU" term="%22Elrod+JW%22">Elrod JW</searchLink>; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA. Electronic address: elrod@temple.edu.
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  Data: <searchLink fieldCode="JN" term="%22101677259%22">JACC. Basic to translational science</searchLink> [JACC Basic Transl Sci] 2025 Sep; Vol. 10 (9), pp. 101334. <i>Date of Electronic Publication: </i>2025 Aug 15.
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