eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR-Mediated Metabolic Rewiring.
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| Title: | eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR-Mediated Metabolic Rewiring. |
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| Authors: | Mittal S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Nenwani M; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA., Pulikkal Kadamberi I; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Kumar S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, 30322, USA., Animasahun O; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA., George J; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Tsaih SW; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Gupta P; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; ECARI, Portland Cancer Research Center, Portland, OR, 97239, USA., Singh M; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Geethadevi A; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Dey C; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Meurs N; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA., Shankaran A; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA., Chaluvally Raghavan P; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Nagrath D; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48106, USA., Pradeep S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. |
| Source: | Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (42), pp. e06307. Date of Electronic Publication: 2025 Aug 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2198-3844 |
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| DOI: | 10.1002/advs.202506307 |
