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eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR-Mediated Metabolic Rewiring.

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Title: eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR-Mediated Metabolic Rewiring.
Authors: Mittal S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Nenwani M; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA., Pulikkal Kadamberi I; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Kumar S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, 30322, USA., Animasahun O; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA., George J; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Tsaih SW; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Gupta P; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; ECARI, Portland Cancer Research Center, Portland, OR, 97239, USA., Singh M; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Geethadevi A; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Dey C; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Meurs N; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA., Shankaran A; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA., Chaluvally Raghavan P; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Nagrath D; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48106, USA., Pradeep S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (42), pp. e06307. Date of Electronic Publication: 2025 Aug 18.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mittal+S%22">Mittal S</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Nenwani+M%22">Nenwani M</searchLink>; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Pulikkal+Kadamberi+I%22">Pulikkal Kadamberi I</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.<br /><searchLink fieldCode="AU" term="%22Animasahun+O%22">Animasahun O</searchLink>; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22George+J%22">George J</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Tsaih+SW%22">Tsaih SW</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+P%22">Gupta P</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; ECARI, Portland Cancer Research Center, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Singh+M%22">Singh M</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Geethadevi+A%22">Geethadevi A</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Dey+C%22">Dey C</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Meurs+N%22">Meurs N</searchLink>; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Shankaran+A%22">Shankaran A</searchLink>; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Chaluvally+Raghavan+P%22">Chaluvally Raghavan P</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Nagrath+D%22">Nagrath D</searchLink>; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48106, USA.<br /><searchLink fieldCode="AU" term="%22Pradeep+S%22">Pradeep S</searchLink>; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
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