Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM.

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Title: Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM.
Authors: Cook DR; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Boesteanu AC; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Yin Y; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Glioblastoma Translational Center of Excellence, Abramson Cancer Center and Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Reid R; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Roccograndi L; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Dahmane N; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Martinez-Lage M; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States., O'Rourke DM; Glioblastoma Translational Center of Excellence, Abramson Cancer Center and Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., June CH; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States., Johnson LA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
Source: Frontiers in immunology [Front Immunol] 2025 Jul 31; Vol. 16, pp. 1579925. Date of Electronic Publication: 2025 Jul 31 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2025.1579925