Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial.
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| Title: | Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial. |
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| Authors: | Flores BN; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; insitro, South San Francisco, CA, 94080, USA., Yu SB; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Cohen IV; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Fanok MH; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Luan W; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia., Maciuca RD; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Sun LD; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Tsai RM; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Vissers M; Centre for Human Drug Research; Zernikedreef 8, 2333 CL, Leiden, the Netherlands., Smits L; Centre for Human Drug Research; Zernikedreef 8, 2333 CL, Leiden, the Netherlands.; Leiden University Medical Center; Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Bunte TM; The University Medical Center Utrecht; Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands., Bakardjiev A; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Gilead Sciences Inc., Foster City, CA, 94404, USA., Balasundar S; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Calvert MEK; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Chin MY; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Dobbins SK; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Dowdle WE; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Altos Labs, Redwood City, CA, 94065, USA., Fang M; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Heuberger JAAC; Centre for Human Drug Research; Zernikedreef 8, 2333 CL, Leiden, the Netherlands., Ha CL; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Huang F; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Takeda Pharmaceuticals America, Inc., Boston, MA, 02215, USA., Miyamoto T; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Osipov M; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Septerna, South San Francisco, CA, 94080, USA., Madrid San Martin L; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia., Saund K; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Tatarakis D; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Vu AQ; Dept of Cellular and Molecular Medicine, University of California; San Diego, La Jolla, CA, 92037, USA., Xiong C; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Gilead Sciences Inc., Foster City, CA, 94404, USA., Yeo GW; Dept of Cellular and Molecular Medicine, University of California; San Diego, La Jolla, CA, 92037, USA.; Sanford Stem Cell Institute and Stem Cell Program, UC San Diego, La Jolla, CA, 92037, USA.; Institute for Genomic Medicine, UC San Diego, La Jolla, CA, 92037, USA.; Sanford Laboratories for Innovative Medicines, La Jolla, CA, 92037, USA., Groeneveld GJ; Centre for Human Drug Research; Zernikedreef 8, 2333 CL, Leiden, the Netherlands.; Leiden University Medical Center; Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., van den Berg LH; The University Medical Center Utrecht; Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands., Dhuria S; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Estrada AA; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Tenvie Therapeutics Inc., South San Francisco, CA, 94080, USA., Jennings D; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Sandmann T; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Ho C; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Scearce-Levie K; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Takeda Pharmaceuticals America, Inc., Boston, MA, 02215, USA., Yulyaningsih E; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Tenvie Therapeutics Inc., South San Francisco, CA, 94080, USA., Walker AK; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia., Di Paolo G; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. dipaolo@dnli.com., Kane LA; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. lesleykane@gmail.com., Troyer MD; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. troyer@dnli.com., Lewcock JW; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. lewcock@dnli.com. |
| Source: | Nature communications [Nat Commun] 2025 Aug 18; Vol. 16 (1), pp. 7690. Date of Electronic Publication: 2025 Aug 18. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40825784 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Flores+BN%22">Flores BN</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; insitro, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Yu+SB%22">Yu SB</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+IV%22">Cohen IV</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Fanok+MH%22">Fanok MH</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Luan+W%22">Luan W</searchLink>; 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Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Osipov+M%22">Osipov M</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Septerna, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Madrid+San+Martin+L%22">Madrid San Martin L</searchLink>; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Saund+K%22">Saund K</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Tatarakis+D%22">Tatarakis D</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Vu+AQ%22">Vu AQ</searchLink>; Dept of Cellular and Molecular Medicine, University of California; San Diego, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Xiong+C%22">Xiong C</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Gilead Sciences Inc., Foster City, CA, 94404, USA.<br /><searchLink fieldCode="AU" term="%22Yeo+GW%22">Yeo GW</searchLink>; Dept of Cellular and Molecular Medicine, University of California; San Diego, La Jolla, CA, 92037, USA.; Sanford Stem Cell Institute and Stem Cell Program, UC San Diego, La Jolla, CA, 92037, USA.; Institute for Genomic Medicine, UC San Diego, La Jolla, CA, 92037, USA.; Sanford Laboratories for Innovative Medicines, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Groeneveld+GJ%22">Groeneveld GJ</searchLink>; Centre for Human Drug Research; Zernikedreef 8, 2333 CL, Leiden, the Netherlands.; Leiden University Medical Center; Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Berg+LH%22">van den Berg LH</searchLink>; 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Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. lesleykane@gmail.com.<br /><searchLink fieldCode="AU" term="%22Troyer+MD%22">Troyer MD</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. troyer@dnli.com.<br /><searchLink fieldCode="AU" term="%22Lewcock+JW%22">Lewcock JW</searchLink>; Denali Therapeutics Inc.; 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. lewcock@dnli.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Aug 18; Vol. 16 (1), pp. 7690. <i>Date of Electronic Publication: </i>2025 Aug 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-025-63031-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 7690 Titles: – TitleFull: Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Flores BN – PersonEntity: Name: NameFull: Yu SB – PersonEntity: Name: NameFull: Cohen IV – PersonEntity: Name: NameFull: Fanok MH – PersonEntity: Name: NameFull: Luan W – PersonEntity: Name: NameFull: Maciuca RD – PersonEntity: Name: NameFull: Sun LD – PersonEntity: Name: NameFull: Tsai RM – PersonEntity: Name: NameFull: Vissers M – PersonEntity: Name: NameFull: Smits L – PersonEntity: Name: NameFull: Bunte TM – PersonEntity: Name: NameFull: Bakardjiev A – PersonEntity: Name: NameFull: Balasundar S – PersonEntity: Name: NameFull: Calvert MEK – PersonEntity: Name: NameFull: Chin MY – PersonEntity: Name: NameFull: Dobbins SK – PersonEntity: Name: NameFull: Dowdle WE – PersonEntity: Name: NameFull: Fang M – PersonEntity: Name: NameFull: Heuberger JAAC – PersonEntity: Name: NameFull: Ha CL – PersonEntity: Name: NameFull: Huang F – PersonEntity: Name: NameFull: Miyamoto T – PersonEntity: Name: NameFull: Osipov M – PersonEntity: Name: NameFull: Madrid San Martin L – PersonEntity: Name: NameFull: Saund K – PersonEntity: Name: NameFull: Tatarakis D – PersonEntity: Name: NameFull: Vu AQ – PersonEntity: Name: NameFull: Xiong C – PersonEntity: Name: NameFull: Yeo GW – PersonEntity: Name: NameFull: Groeneveld GJ – PersonEntity: Name: NameFull: van den Berg LH – PersonEntity: Name: NameFull: Dhuria S – PersonEntity: Name: NameFull: Estrada AA – PersonEntity: Name: NameFull: Jennings D – PersonEntity: Name: NameFull: Sandmann T – PersonEntity: Name: NameFull: Ho C – PersonEntity: Name: NameFull: Scearce-Levie K – PersonEntity: Name: NameFull: Yulyaningsih E – PersonEntity: Name: NameFull: Walker AK – PersonEntity: Name: NameFull: Di Paolo G – PersonEntity: Name: NameFull: Kane LA – PersonEntity: Name: NameFull: Troyer MD – PersonEntity: Name: NameFull: Lewcock JW IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 08 Text: 2025 Aug 18 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
| ResultId | 1 |
