JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer.
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| Title: | JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer. |
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| Authors: | Alexandrou S; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Lee CS; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Fernandez KJ; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Wiharja CE; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Eshraghi L; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Reeves J; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Reed DA; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Portman N; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Phan Z; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Milioli HH; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Nikolic I; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Cadell AL; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Croucher DR; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Simpson KJ; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC, Australia., Lim E; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Hickey TE; Dame Roma Mitchell Cancer Research Adelaide Medical School Laboratories, University of Adelaide, Adelaide, Australia., Millar EKA; Department of Anatomical Pathology, NSW Health Pathology, St George Hospital, Sydney, NSW, Australia.; St George & Sutherland Campus, School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia., Alves CL; Department of Molecular Medicine, Cancer Research Unit, University of Southern Denmark, Odense, Denmark., Ditzel HJ; Department of Molecular Medicine, Cancer Research Unit, University of Southern Denmark, Odense, Denmark.; Department of Oncology, Odense University Hospital, Odense, Denmark., Caldon CE; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia. l.caldon@garvan.org.au.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia. l.caldon@garvan.org.au. |
| Source: | Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2025 Aug 19; Vol. 44 (1), pp. 244. Date of Electronic Publication: 2025 Aug 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1756-9966 |
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| DOI: | 10.1186/s13046-025-03466-9 |
