Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids.
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| Title: | Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids. |
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| Authors: | Yeisley DJ; U.S. Food and Drug Administration, National Center for Toxicological Research (NCTR), Jefferson, AR, USA., Ren L; U.S. Food and Drug Administration, National Center for Toxicological Research (NCTR), Jefferson, AR, USA., Papineau KS; U.S. Food and Drug Administration, National Center for Toxicological Research (NCTR), Jefferson, AR, USA., Schnackenberg LK; U.S. Food and Drug Administration, National Center for Toxicological Research (NCTR), Jefferson, AR, USA., Gamboa da Costa G; U.S. Food and Drug Administration, National Center for Toxicological Research (NCTR), Jefferson, AR, USA., Patterson TA; U.S. Food and Drug Administration, National Center for Toxicological Research (NCTR), Jefferson, AR, USA., Fitzpatrick SC; U.S. Food and Drug Administration, Human Foods Program, College Park, MD, USA., Shi Q; U.S. Food and Drug Administration, National Center for Toxicological Research (NCTR), Jefferson, AR, USA. |
| Source: | Biochemistry and biophysics reports [Biochem Biophys Rep] 2025 Aug 11; Vol. 43, pp. 102199. Date of Electronic Publication: 2025 Aug 11 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101660999 Publication Model: eCollection Cited Medium: Internet ISSN: 2405-5808 (Electronic) Linking ISSN: 24055808 NLM ISO Abbreviation: Biochem Biophys Rep Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 2405-5808 |
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| DOI: | 10.1016/j.bbrep.2025.102199 |
