mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice.

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Title: mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice.
Authors: Limsalakpetch A; Department of Bacterial and Parasitic Diseases, WRAIR-AFRIMS, Bangkok 10400, Thailand., Kum-Arb U; Department of Bacterial and Parasitic Diseases, WRAIR-AFRIMS, Bangkok 10400, Thailand., Yongvanitchit K; Department of Bacterial and Parasitic Diseases, WRAIR-AFRIMS, Bangkok 10400, Thailand., Im-Erbsin R; Department of Bacterial and Parasitic Diseases, WRAIR-AFRIMS, Bangkok 10400, Thailand., Ubalee R; Department of Bacterial and Parasitic Diseases, WRAIR-AFRIMS, Bangkok 10400, Thailand., Waters N; Department of Bacterial and Parasitic Diseases, WRAIR-AFRIMS, Bangkok 10400, Thailand., Vesely BA; Department of Bacterial and Parasitic Diseases, WRAIR-AFRIMS, Bangkok 10400, Thailand., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Weissman D; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tam YK; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Yoshida S; Laboratory of Vaccinology and Applied Immunology, School of Pharmacy, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan., Adams J; Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida, Tampa, FL 33612, USA., Yadava A; Biologics Research & Development Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Pichyangkul S; Department of Bacterial and Parasitic Diseases, WRAIR-AFRIMS, Bangkok 10400, Thailand.
Source: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2025 Jul 30; Vol. 36 (3), pp. 102645. Date of Electronic Publication: 2025 Jul 30 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2162-2531
DOI:10.1016/j.omtn.2025.102645