Preclinical and clinical evaluation of LY3451838, a PACAP-neutralizing monoclonal antibody, in randomized, double-blind, placebo-controlled phase 1 and phase 2 studies involving healthy adults and adults with treatment-resistant migraine.
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| Title: | Preclinical and clinical evaluation of LY3451838, a PACAP-neutralizing monoclonal antibody, in randomized, double-blind, placebo-controlled phase 1 and phase 2 studies involving healthy adults and adults with treatment-resistant migraine. |
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| Authors: | Johnson MP; Eli Lilly and Company, Indianapolis, IN, USA., Krikke-Workel J; Eli Lilly and Company, Indianapolis, IN, USA., Patel CN; Eli Lilly and Company, Indianapolis, IN, USA., Morin SM; Eli Lilly and Company, Indianapolis, IN, USA., Turner PK; Eli Lilly and Company, Indianapolis, IN, USA., Clark KA; Eli Lilly and Company, Indianapolis, IN, USA., Donley D; EMB Statistical Solutions, LLC, Overland Park, KS, USA., Jin Y; Eli Lilly and Company, Indianapolis, IN, USA., Johnson KW; Eli Lilly and Company, Indianapolis, IN, USA., Vincent M; Eli Lilly and Company, Indianapolis, IN, USA., Stille JR; Eli Lilly and Company, Indianapolis, IN, USA., Broad LM; Eli Lilly and Company, Indianapolis, IN, USA., Patel A; Bio Behavioral Health, Toms River, NJ, USA. |
| Source: | Cephalalgia : an international journal of headache [Cephalalgia] 2025 Aug; Vol. 45 (8), pp. 3331024251368757. Date of Electronic Publication: 2025 Aug 21. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Country of Publication: England NLM ID: 8200710 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2982 (Electronic) Linking ISSN: 03331024 NLM ISO Abbreviation: Cephalalgia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1468-2982 |
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| DOI: | 10.1177/03331024251368757 |
