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Preclinical and clinical evaluation of LY3451838, a PACAP-neutralizing monoclonal antibody, in randomized, double-blind, placebo-controlled phase 1 and phase 2 studies involving healthy adults and adults with treatment-resistant migraine.

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Title: Preclinical and clinical evaluation of LY3451838, a PACAP-neutralizing monoclonal antibody, in randomized, double-blind, placebo-controlled phase 1 and phase 2 studies involving healthy adults and adults with treatment-resistant migraine.
Authors: Johnson MP; Eli Lilly and Company, Indianapolis, IN, USA., Krikke-Workel J; Eli Lilly and Company, Indianapolis, IN, USA., Patel CN; Eli Lilly and Company, Indianapolis, IN, USA., Morin SM; Eli Lilly and Company, Indianapolis, IN, USA., Turner PK; Eli Lilly and Company, Indianapolis, IN, USA., Clark KA; Eli Lilly and Company, Indianapolis, IN, USA., Donley D; EMB Statistical Solutions, LLC, Overland Park, KS, USA., Jin Y; Eli Lilly and Company, Indianapolis, IN, USA., Johnson KW; Eli Lilly and Company, Indianapolis, IN, USA., Vincent M; Eli Lilly and Company, Indianapolis, IN, USA., Stille JR; Eli Lilly and Company, Indianapolis, IN, USA., Broad LM; Eli Lilly and Company, Indianapolis, IN, USA., Patel A; Bio Behavioral Health, Toms River, NJ, USA.
Source: Cephalalgia : an international journal of headache [Cephalalgia] 2025 Aug; Vol. 45 (8), pp. 3331024251368757. Date of Electronic Publication: 2025 Aug 21.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Country of Publication: England NLM ID: 8200710 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2982 (Electronic) Linking ISSN: 03331024 NLM ISO Abbreviation: Cephalalgia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Preclinical and clinical evaluation of LY3451838, a PACAP-neutralizing monoclonal antibody, in randomized, double-blind, placebo-controlled phase 1 and phase 2 studies involving healthy adults and adults with treatment-resistant migraine.
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  Data: <searchLink fieldCode="JN" term="%228200710%22">Cephalalgia : an international journal of headache</searchLink> [Cephalalgia] 2025 Aug; Vol. 45 (8), pp. 3331024251368757. <i>Date of Electronic Publication: </i>2025 Aug 21.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22%22"> </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8200710 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-2982 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203331024%22">03331024 </searchLink><i>NLM ISO Abbreviation: </i>Cephalalgia <i>Subsets: </i>MEDLINE
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        Text: English
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              Text: 2025 Aug
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