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Image-based drug screening combined with molecular profiling identifies signatures and drivers of therapy resistance in pediatric AML.

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Title: Image-based drug screening combined with molecular profiling identifies signatures and drivers of therapy resistance in pediatric AML.
Authors: Haladik B; St. Anna Children's Cancer Research Institute, Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Maurer-Granofszky M; St. Anna Children's Cancer Research Institute, Vienna, Austria., Zoescher P; St. Anna Children's Cancer Research Institute, Vienna, Austria., Jimenez-Heredia R; St. Anna Children's Cancer Research Institute, Vienna, Austria; Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Vienna, Austria., Frohne A; St. Anna Children's Cancer Research Institute, Vienna, Austria., Segarra-Roca A; St. Anna Children's Cancer Research Institute, Vienna, Austria., Casey C; St. Anna Children's Cancer Research Institute, Vienna, Austria., Kartnig F; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Medical University of Vienna, Department of Internal Medicine III, Division of Rheumatology, Vienna, Austria., Giuliani S; St. Anna Children's Cancer Research Institute, Vienna, Austria., Rashkova C; St. Anna Children's Cancer Research Institute, Vienna, Austria; Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Vienna, Austria., Repiscak P; St. Anna Children's Cancer Research Institute, Vienna, Austria., Dworzak MN; St. Anna Children's Cancer Research Institute, Vienna, Austria; Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Vienna, Austria; St. Anna Children's Hospital, Vienna, Austria., Superti-Furga G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Medical University of Vienna, Center for Physiology and Pharmacology, Vienna, Austria., Boztug K; St. Anna Children's Cancer Research Institute, Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Vienna, Austria; St. Anna Children's Hospital, Vienna, Austria; Clinic for Pediatric Immunology and Rheumatology, Center for Pediatrics and Adolescent Medicine, University Hospital Bonn, Bonn, Germany. Electronic address: kaan.boztug@ccri.at.
Source: Cell reports. Medicine [Cell Rep Med] 2025 Sep 16; Vol. 6 (9), pp. 102304. Date of Electronic Publication: 2025 Aug 20.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-3791
DOI:10.1016/j.xcrm.2025.102304