Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition.
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| Title: | Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition. |
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| Authors: | Ringnalda FCAS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., van Son GJF; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Verweij LHG; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Kim SY; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Amo-Addae V; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Flucke UE; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Hiemcke-Jiwa LS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands., Langenberg KPS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Bramer JAM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Heimans L; Sarcomas and GIST Center, Netherlands Cancer Institute-Antoni van Leeuwenhoek (NKI-AVL), Amsterdam, The Netherlands., van de Sande MAJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., van Houdt WJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek (NKI-AVL), Amsterdam, The Netherlands., van Noesel MM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Kerstens HHD; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Santoso M; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Seifert G; Department of Pediatrics, Division of Oncology and Hematology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Delattre O; Institut Curie Research Center, NSERM U1330, Diversity and Plasticity of Pediatric Sarcoma Lab, PSL Research University, SIREDO Oncology Center, Paris, France., Scotlandi K; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Geoerger B; Department of Pediatric and Adolescent Oncology, INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Paris, France., Merks JHM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Division of Imaging and Oncology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., van Boxtel R; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., van de Wetering M; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Sanders K; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. k.sanders@prinsesmaximacentrum.nl.; Oncode Institute, Utrecht, The Netherlands. k.sanders@prinsesmaximacentrum.nl., Clevers H; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. h.clevers@hubrecht.eu.; Oncode Institute, Utrecht, The Netherlands. h.clevers@hubrecht.eu.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, The Netherlands. h.clevers@hubrecht.eu.; Pharma, Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Basel, Switzerland. h.clevers@hubrecht.eu. |
| Source: | Nature communications [Nat Commun] 2025 Aug 21; Vol. 16 (1), pp. 7689. Date of Electronic Publication: 2025 Aug 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-62673-2 |
