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Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition.

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Title: Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition.
Authors: Ringnalda FCAS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., van Son GJF; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Verweij LHG; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Kim SY; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Amo-Addae V; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Flucke UE; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Hiemcke-Jiwa LS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands., Langenberg KPS; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Bramer JAM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Heimans L; Sarcomas and GIST Center, Netherlands Cancer Institute-Antoni van Leeuwenhoek (NKI-AVL), Amsterdam, The Netherlands., van de Sande MAJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., van Houdt WJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek (NKI-AVL), Amsterdam, The Netherlands., van Noesel MM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Kerstens HHD; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Santoso M; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Seifert G; Department of Pediatrics, Division of Oncology and Hematology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Delattre O; Institut Curie Research Center, NSERM U1330, Diversity and Plasticity of Pediatric Sarcoma Lab, PSL Research University, SIREDO Oncology Center, Paris, France., Scotlandi K; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Geoerger B; Department of Pediatric and Adolescent Oncology, INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Paris, France., Merks JHM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Division of Imaging and Oncology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., van Boxtel R; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., van de Wetering M; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Sanders K; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. k.sanders@prinsesmaximacentrum.nl.; Oncode Institute, Utrecht, The Netherlands. k.sanders@prinsesmaximacentrum.nl., Clevers H; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. h.clevers@hubrecht.eu.; Oncode Institute, Utrecht, The Netherlands. h.clevers@hubrecht.eu.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, The Netherlands. h.clevers@hubrecht.eu.; Pharma, Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Basel, Switzerland. h.clevers@hubrecht.eu.
Source: Nature communications [Nat Commun] 2025 Aug 21; Vol. 16 (1), pp. 7689. Date of Electronic Publication: 2025 Aug 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Ringnalda+FCAS%22">Ringnalda FCAS</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Son+GJF%22">van Son GJF</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Verweij+LHG%22">Verweij LHG</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kim+SY%22">Kim SY</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Amo-Addae+V%22">Amo-Addae V</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Flucke+UE%22">Flucke UE</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hiemcke-Jiwa+LS%22">Hiemcke-Jiwa LS</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Langenberg+KPS%22">Langenberg KPS</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bramer+JAM%22">Bramer JAM</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Heimans+L%22">Heimans L</searchLink>; Sarcomas and GIST Center, Netherlands Cancer Institute-Antoni van Leeuwenhoek (NKI-AVL), Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Sande+MAJ%22">van de Sande MAJ</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Houdt+WJ%22">van Houdt WJ</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek (NKI-AVL), Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Noesel+MM%22">van Noesel MM</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kerstens+HHD%22">Kerstens HHD</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Santoso+M%22">Santoso M</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Seifert+G%22">Seifert G</searchLink>; Department of Pediatrics, Division of Oncology and Hematology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Delattre+O%22">Delattre O</searchLink>; Institut Curie Research Center, NSERM U1330, Diversity and Plasticity of Pediatric Sarcoma Lab, PSL Research University, SIREDO Oncology Center, Paris, France.<br /><searchLink fieldCode="AU" term="%22Scotlandi+K%22">Scotlandi K</searchLink>; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Geoerger+B%22">Geoerger B</searchLink>; Department of Pediatric and Adolescent Oncology, INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Paris, France.<br /><searchLink fieldCode="AU" term="%22Merks+JHM%22">Merks JHM</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Division of Imaging and Oncology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Molenaar+JJ%22">Molenaar JJ</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Boxtel+R%22">van Boxtel R</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Wetering+M%22">van de Wetering M</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sanders+K%22">Sanders K</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. k.sanders@prinsesmaximacentrum.nl.; Oncode Institute, Utrecht, The Netherlands. k.sanders@prinsesmaximacentrum.nl.<br /><searchLink fieldCode="AU" term="%22Clevers+H%22">Clevers H</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. h.clevers@hubrecht.eu.; Oncode Institute, Utrecht, The Netherlands. h.clevers@hubrecht.eu.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, The Netherlands. h.clevers@hubrecht.eu.; Pharma, Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Basel, Switzerland. h.clevers@hubrecht.eu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Aug 21; Vol. 16 (1), pp. 7689. <i>Date of Electronic Publication: </i>2025 Aug 21.
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