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HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates.

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Title: HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates.
Authors: Ma KM; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Sutton HJ; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Pratap PP; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Steichen JM; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Carnathan D; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA., Quinn J; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Kalyuzhniy O; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Liguori A; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Agrawal S; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Baboo S; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Madden P; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Cottrell CA; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Willis JR; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Lee JH; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Landais E; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Hu X; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Ramezani-Rad P; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Ozorowski G; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Lewis VR; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA., Diedrich JK; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Zhou X; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Altheide TK; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Phelps N; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Georgeson E; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Alavi NB; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Lu D; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Eskandarzadeh S; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Kubitz M; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Adachi Y; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Mullen TM; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Silva M; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA., Melo MB; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Himansu S; Moderna Inc., Cambridge, MA 02139, USA., Irvine DJ; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.; Department of Materials Science and Engineering, MIT, Cambridge, MA 02139, USA.; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.; Ragon Institute of Massachusetts General Hospital, Cambridge, MA 02139, USA., Burton DR; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Yates JR 3rd; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Paulson JC; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Sok D; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Wilson IA; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Silvestri G; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA., Ward AB; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Crotty S; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, 92037 USA., Schief WR; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Moderna Inc., Cambridge, MA 02139, USA.
Source: Science immunology [Sci Immunol] 2025 Aug 22; Vol. 10 (110), pp. eadt6660. Date of Electronic Publication: 2025 Aug 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2470-9468
DOI:10.1126/sciimmunol.adt6660