Predictive value of subgenual cingulate normative connectivity to TMS treatment site for antidepressant response in routine clinical practice: a prospective, multisite cohort study.

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Title: Predictive value of subgenual cingulate normative connectivity to TMS treatment site for antidepressant response in routine clinical practice: a prospective, multisite cohort study.
Authors: Khosravani S; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. skhosravani@mgb.org.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. skhosravani@mgb.org., Palm ST; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Drew W; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Frandsen SB; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lin C; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Tirrell E; Butler Hospital TMS Clinic and Neuromodulation Research Facility, Providence, RI, USA., Hindley L; Butler Hospital TMS Clinic and Neuromodulation Research Facility, Providence, RI, USA., Schineller M; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Garimella A; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Chiulli N; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lawson D; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Jones E; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Press DZ; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Stern AP; Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Brown JC; McLean Hospital, Harvard Medical School, Belmont, MA, USA., Barbour TA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Taylor JJ; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Carpenter LL; Butler Hospital TMS Clinic and Neuromodulation Research Facility, Providence, RI, USA.; Department of Psychiatry and Human Behavior, Warren Alpert Medical School at Brown University, Providence, RI, USA., Siddiqi SH; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Fox MD; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mdfox@bwh.harvard.edu.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mdfox@bwh.harvard.edu.; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mdfox@bwh.harvard.edu.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mdfox@bwh.harvard.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Feb; Vol. 31 (2), pp. 689-700. Date of Electronic Publication: 2025 Aug 22.
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03153-3