Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics.

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Title: Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics.
Authors: Ooi SA; Department of Chemistry and Molecular Biology, Medicinaregatan 7B, Gothenburg 413 90, Sweden., Valli D; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden., Kuska MI; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden., Marí H; Pathogenesis and Prevention of Diabetes Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain., Chaudhary H; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden., Wahlgren WY; Department of Chemistry and Molecular Biology, Medicinaregatan 7B, Gothenburg 413 90, Sweden., Westenhoff S; Department of Chemistry - BMC, Biochemistry, Uppsala University, Uppsala 75123, Sweden., Tietze AA; Department of Chemistry and Molecular Biology, Medicinaregatan 7B, Gothenburg 413 90, Sweden., Novials A; Pathogenesis and Prevention of Diabetes Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain., Servitja JM; Pathogenesis and Prevention of Diabetes Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain., Maj M; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden. Electronic address: michal.maj@kemi.uu.se.
Source: Journal of molecular biology [J Mol Biol] 2025 Nov 01; Vol. 437 (21), pp. 169405. Date of Electronic Publication: 2025 Aug 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1089-8638
DOI:10.1016/j.jmb.2025.169405