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Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics.

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Title: Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics.
Authors: Ooi SA; Department of Chemistry and Molecular Biology, Medicinaregatan 7B, Gothenburg 413 90, Sweden., Valli D; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden., Kuska MI; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden., Marí H; Pathogenesis and Prevention of Diabetes Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain., Chaudhary H; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden., Wahlgren WY; Department of Chemistry and Molecular Biology, Medicinaregatan 7B, Gothenburg 413 90, Sweden., Westenhoff S; Department of Chemistry - BMC, Biochemistry, Uppsala University, Uppsala 75123, Sweden., Tietze AA; Department of Chemistry and Molecular Biology, Medicinaregatan 7B, Gothenburg 413 90, Sweden., Novials A; Pathogenesis and Prevention of Diabetes Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain., Servitja JM; Pathogenesis and Prevention of Diabetes Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain., Maj M; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden. Electronic address: michal.maj@kemi.uu.se.
Source: Journal of molecular biology [J Mol Biol] 2025 Nov 01; Vol. 437 (21), pp. 169405. Date of Electronic Publication: 2025 Aug 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
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  Data: Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics.
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  Data: <searchLink fieldCode="AU" term="%22Ooi+SA%22">Ooi SA</searchLink>; Department of Chemistry and Molecular Biology, Medicinaregatan 7B, Gothenburg 413 90, Sweden.<br /><searchLink fieldCode="AU" term="%22Valli+D%22">Valli D</searchLink>; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden.<br /><searchLink fieldCode="AU" term="%22Kuska+MI%22">Kuska MI</searchLink>; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden.<br /><searchLink fieldCode="AU" term="%22Marí+H%22">Marí H</searchLink>; Pathogenesis and Prevention of Diabetes Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.<br /><searchLink fieldCode="AU" term="%22Chaudhary+H%22">Chaudhary H</searchLink>; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden.<br /><searchLink fieldCode="AU" term="%22Wahlgren+WY%22">Wahlgren WY</searchLink>; Department of Chemistry and Molecular Biology, Medicinaregatan 7B, Gothenburg 413 90, Sweden.<br /><searchLink fieldCode="AU" term="%22Westenhoff+S%22">Westenhoff S</searchLink>; Department of Chemistry - BMC, Biochemistry, Uppsala University, Uppsala 75123, Sweden.<br /><searchLink fieldCode="AU" term="%22Tietze+AA%22">Tietze AA</searchLink>; Department of Chemistry and Molecular Biology, Medicinaregatan 7B, Gothenburg 413 90, Sweden.<br /><searchLink fieldCode="AU" term="%22Novials+A%22">Novials A</searchLink>; Pathogenesis and Prevention of Diabetes Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.<br /><searchLink fieldCode="AU" term="%22Servitja+JM%22">Servitja JM</searchLink>; Pathogenesis and Prevention of Diabetes Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.<br /><searchLink fieldCode="AU" term="%22Maj+M%22">Maj M</searchLink>; Department of Chemistry - Ångström Laboratory, Uppsala University, Box 523, Uppsala 751 20, Sweden. Electronic address: michal.maj@kemi.uu.se.
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  Data: <searchLink fieldCode="JN" term="%222985088R%22">Journal of molecular biology</searchLink> [J Mol Biol] 2025 Nov 01; Vol. 437 (21), pp. 169405. <i>Date of Electronic Publication: </i>2025 Aug 22.
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