SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis.
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| Title: | SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis. |
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| Authors: | Perla S; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520., Stiegler AL; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520., Yi JS; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520., Enyenihi L; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.; Division of Genetics and Genomics and Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02215., Zhang L; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520., Riaz M; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511., An E; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520., Qyang Y; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511., Boggon TJ; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520., Bennett AM; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.; Yale Center for Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT 06520. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Sep 02; Vol. 122 (35), pp. e2503631122. Date of Electronic Publication: 2025 Aug 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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