Impact of enhanced infection control and antimicrobial stewardship on infections by Clostridioides difficile, vancomycin-resistant enterococci, and third-generation cephalosporin-resistant Enterobacterales: a stepped-wedge cluster intervention study.

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Title: Impact of enhanced infection control and antimicrobial stewardship on infections by Clostridioides difficile, vancomycin-resistant enterococci, and third-generation cephalosporin-resistant Enterobacterales: a stepped-wedge cluster intervention study.
Authors: Classen AY; Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany. Electronic address: annika.classen@uk-koeln.de., Dietz T; Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany; Institute of Medical Sociology, Health Services Research, and Rehabilitation Science (IMVR), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Graeff LD; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany., Eisenbeis S; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Division of Infectious Diseases, Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Gastmeier P; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Institute of Hygiene and Environmental Medicine, Charité-Universitétsmedizin corporate member of Freie Universität Berlin, and Humboldt-Universität zu Berlin and Berlin Institute of health, Berlin, Germany., Göpel S; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Division of Infectious Diseases, Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Hoffmann A; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hölzl F; Division of Infectious Diseases, Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Käding N; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Infectious Disease Clinic and Institute of Medical Microbiology, University of Lübeck, Lübeck, Germany., Kern WV; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Division of Infectious Diseases, Department of Medicine II, Medical Center, University of Freiburg, Freiburg im Breisgau, Germany., Kramme E; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Infectious Disease Clinic and Institute of Medical Microbiology, University of Lübeck, Lübeck, Germany., Belmar Campos C; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Maurer FP; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Seifert H; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Institute of Translational Research, Cologne Excellence Cluster for Aging and Aging-Associated Diseases, University of Cologne, Cologne, Germany., Meißner A; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Institute of Hygiene and Environmental Medicine, Charité-Universitétsmedizin corporate member of Freie Universität Berlin, and Humboldt-Universität zu Berlin and Berlin Institute of health, Berlin, Germany., Rohde AM; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Institute of Hygiene and Environmental Medicine, Charité-Universitétsmedizin corporate member of Freie Universität Berlin, and Humboldt-Universität zu Berlin and Berlin Institute of health, Berlin, Germany., Rohde H; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rupp J; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Infectious Disease Clinic and Institute of Medical Microbiology, University of Lübeck, Lübeck, Germany., Tacconelli E; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Division of Infectious Diseases, Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Walker SV; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Zweigner J; Infectious Disease Clinic and Institute of Medical Microbiology, University of Lübeck, Lübeck, Germany; Department of Hospital Hygiene and Infection Control, University Hospital of Cologne, Cologne, Germany., Vehreschild JJ; Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung e.V., DZIF e.V.), Braunschweig, Germany; Institute for Digital Medicine and Clinical Data Sciences, Faculty of Medicine and University Hospital of Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany.
Corporate Authors: ABSOLUTE (Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives) Study Group
Source: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2025 Dec; Vol. 31 (12), pp. 2025-2032. Date of Electronic Publication: 2025 Aug 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1469-0691
DOI:10.1016/j.cmi.2025.08.013