The mitotic STAG3-cohesin complex shapes male germline nucleome.

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Title: The mitotic STAG3-cohesin complex shapes male germline nucleome.
Authors: Nagano M; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan. nagano@anat2.med.kyoto-u.ac.jp.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. nagano@anat2.med.kyoto-u.ac.jp., Hu B; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Ogata K; Department of Molecular Systems BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Umemura F; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ishikura Y; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Suzuki S; Division of Germ Cell Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, Myodaiji, Japan.; Graduate Institute for Advanced Studies, SOKENDAI, Myodaiji, Japan., Katsifis CC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yoshinaga M; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Litos G; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria., Nagasaka K; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria., Tang W; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria., Nosaka Y; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Sasada H; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Wang H; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kondo D; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Katou Y; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Mizuta K; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yabuta Y; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ohta H; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., de Luna Vitorino FN; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA., Arima H; Department of Hematology, Kyoto University Hospital, Kyoto, Japan., Ichikawa T; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; Department of Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Gabriele M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Majewski J; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Garcia BA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA., Takeuchi O; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yoshida S; Division of Germ Cell Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, Myodaiji, Japan.; Graduate Institute for Advanced Studies, SOKENDAI, Myodaiji, Japan., Hansen AS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Peters JM; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria., Ishihama Y; Department of Molecular Systems BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Saitou M; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan. saitou@anat2.med.kyoto-u.ac.jp.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. saitou@anat2.med.kyoto-u.ac.jp.; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. saitou@anat2.med.kyoto-u.ac.jp.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Nov; Vol. 32 (11), pp. 2203-2218. Date of Electronic Publication: 2025 Aug 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1545-9985
DOI:10.1038/s41594-025-01647-w