Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration.
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| Title: | Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration. |
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| Authors: | Kuo TY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan., Lin TL; Department of Sports Medicine, College of Health Care, China Medical University, Taichung, 406040, Taiwan.; Department of Orthopedics, China Medical University Hospital, Taichung, 404332, Taiwan., Lin YH; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan., Chen CY; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan., Cho DY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, 404332, Taiwan.; Translational Cell Therapy Center, China Medical University Hospital, Taichung, 404332, Taiwan., Chen YW; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan., Shie MY; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan. eric@mail.cmu.edu.tw.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan. eric@mail.cmu.edu.tw.; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 41354, Taiwan. eric@mail.cmu.edu.tw. |
| Source: | Journal of nanobiotechnology [J Nanobiotechnology] 2025 Aug 25; Vol. 23 (1), pp. 586. Date of Electronic Publication: 2025 Aug 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1477-3155 |
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| DOI: | 10.1186/s12951-025-03679-2 |
