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Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration.

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Title: Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration.
Authors: Kuo TY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan., Lin TL; Department of Sports Medicine, College of Health Care, China Medical University, Taichung, 406040, Taiwan.; Department of Orthopedics, China Medical University Hospital, Taichung, 404332, Taiwan., Lin YH; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan., Chen CY; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan., Cho DY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, 404332, Taiwan.; Translational Cell Therapy Center, China Medical University Hospital, Taichung, 404332, Taiwan., Chen YW; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan., Shie MY; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan. eric@mail.cmu.edu.tw.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan. eric@mail.cmu.edu.tw.; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 41354, Taiwan. eric@mail.cmu.edu.tw.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 Aug 25; Vol. 23 (1), pp. 586. Date of Electronic Publication: 2025 Aug 25.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration.
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  Data: <searchLink fieldCode="AU" term="%22Kuo+TY%22">Kuo TY</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+TL%22">Lin TL</searchLink>; Department of Sports Medicine, College of Health Care, China Medical University, Taichung, 406040, Taiwan.; Department of Orthopedics, China Medical University Hospital, Taichung, 404332, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YH%22">Lin YH</searchLink>; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cho+DY%22">Cho DY</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, 404332, Taiwan.; Translational Cell Therapy Center, China Medical University Hospital, Taichung, 404332, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YW%22">Chen YW</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shie+MY%22">Shie MY</searchLink>; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan. eric@mail.cmu.edu.tw.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404332, Taiwan. eric@mail.cmu.edu.tw.; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 41354, Taiwan. eric@mail.cmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2025 Aug 25; Vol. 23 (1), pp. 586. <i>Date of Electronic Publication: </i>2025 Aug 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101152208 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-3155 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214773155%22">14773155 </searchLink><i>NLM ISO Abbreviation: </i>J Nanobiotechnology <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12951-025-03679-2
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        Text: English
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              Text: 2025 Aug 25
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