Deciphering molecular determinants of GPBAR1-Gs protein interactions by HDX-MS and cryo-EM.
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| Title: | Deciphering molecular determinants of GPBAR1-Gs protein interactions by HDX-MS and cryo-EM. |
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| Authors: | Castel J; Department of Biophysics, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France.; Laboratoire de Spectrométrie de Masse BioOrganique, IPHC UMR 7178, Infrastructure Nationale de Protéomique ProFI, Université de Strasbourg, CNRS, UAR2048 CNRS, 67087, Strasbourg, France., Botzanowski T; Department of Biophysics, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France., Brooks I; Department of Structural Biology, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France., Frechard A; Department of Structural Biology, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France., Bey G; Department of Structural Biology, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France., Schroeter M; Department of Structural Biology, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France., Del Nero E; Department of Biophysics, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France., Debaene F; Department of Biophysics, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France., Ciesielski F; Department of Structural Biology, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France., Zeyer D; Department of Biophysics, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France.; Department of Structural Biology, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France., Cianferani S; Laboratoire de Spectrométrie de Masse BioOrganique, IPHC UMR 7178, Infrastructure Nationale de Protéomique ProFI, Université de Strasbourg, CNRS, UAR2048 CNRS, 67087, Strasbourg, France. sarah.cianferani@unistra.fr., Morales R; Department of Biophysics, Novalix, 16 Rue d'Ankara, 67000, Strasbourg, France. rmorales@novalix.com. |
| Source: | Scientific reports [Sci Rep] 2025 Aug 26; Vol. 15 (1), pp. 31517. Date of Electronic Publication: 2025 Aug 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-025-16529-w |