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Discovery of N'-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling.

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Title: Discovery of N'-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling.
Authors: Khaleel EF; Department of Medical Physiology, College of Medicine, King Khalid University, Asir, Saudi Arabia., Abdelmegeed H; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt., Abdel-Razik AH; Department of Histology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt., Ebaid MS; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt.; Department of Chemistry, College of Science, Northern Border University, Arar, Saudi Arabia., Son NT; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Ha NX; Institute of Natural Products Chemistry, VAST, Hanoi, Vietnam., Atef Abdelsattar Ibrahim H; Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Abdelrahman MA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kut, Wasit, Iraq.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt., Elshamy AI; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt., Dziadek J; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland., Sabt A; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Source: Frontiers in chemistry [Front Chem] 2025 Aug 08; Vol. 13, pp. 1621717. Date of Electronic Publication: 2025 Aug 08 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101627988 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2646 (Print) Linking ISSN: 22962646 NLM ISO Abbreviation: Front Chem Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of N'-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling.
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  Data: <searchLink fieldCode="AU" term="%22Khaleel+EF%22">Khaleel EF</searchLink>; Department of Medical Physiology, College of Medicine, King Khalid University, Asir, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abdelmegeed+H%22">Abdelmegeed H</searchLink>; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdel-Razik+AH%22">Abdel-Razik AH</searchLink>; Department of Histology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt.<br /><searchLink fieldCode="AU" term="%22Ebaid+MS%22">Ebaid MS</searchLink>; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt.; Department of Chemistry, College of Science, Northern Border University, Arar, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Son+NT%22">Son NT</searchLink>; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Ha+NX%22">Ha NX</searchLink>; Institute of Natural Products Chemistry, VAST, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Atef+Abdelsattar+Ibrahim+H%22">Atef Abdelsattar Ibrahim H</searchLink>; Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelrahman+MA%22">Abdelrahman MA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kut, Wasit, Iraq.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Elshamy+AI%22">Elshamy AI</searchLink>; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Dziadek+J%22">Dziadek J</searchLink>; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland.<br /><searchLink fieldCode="AU" term="%22Sabt+A%22">Sabt A</searchLink>; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Eldehna+WM%22">Eldehna WM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101627988%22">Frontiers in chemistry</searchLink> [Front Chem] 2025 Aug 08; Vol. 13, pp. 1621717. <i>Date of Electronic Publication: </i>2025 Aug 08 (<i>Print Publication: </i>2025).
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