Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis.
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| Title: | Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis. |
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| Authors: | McLoughlin MA; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Cheloor Kovilakam S; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Dunn WG; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Gu M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Tobin J; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Pershad Y; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Williams N; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Leongamornlert D; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Dawson K; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Bond L; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Marando L; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Hematology, Mayo Clinic, Rochester, MI, USA., Wen S; Department of Haematology, University of Cambridge, Cambridge, UK.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wilson R; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Valenzano G; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Symeonidou V; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Rak J; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Damaskou A; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Gozdecka M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Liu X; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Barcena C; Department of Biochemistry and Molecular Biology, Instituto Universitario de Oncología (IUOPA),Universidad de Oviedo, Oviedo, Spain., Nomdedeu J; Hospital Sant Pau, Barcelona, Spain., Costeas P; Centre for the Study of Haematological Malignancies, Nicosia, Cyprus., Dimitriou ID; Cyprus Cancer Research Institute, Nicosia, Cyprus., Fiorillo E; Institute for Genetic and Biomedical Research, National Research Council, Lanusei, Italy., Orrù V; Institute for Genetic and Biomedical Research, National Research Council, Lanusei, Italy., de Almeida JG; Computational Clinical Imaging Group, Champalimaud Foundation, Lisbon, Portugal., McKerrell T; Department of Haematology, University Hospital Geelong, Geelong, Victoria, Australia.; School of Medicine, Deakin University Geelong, Geelong, Victoria, Australia., Cullen M; Department of Haematology, University of Cambridge, Cambridge, UK., Mohorianu I; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Foukaneli T; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Warren AJ; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Wong C; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Follows G; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Godfrey AL; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Gudgin E; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Cucca F; Institute for Genetic and Biomedical Research, National Research Council, Lanusei, Italy.; Department of Biomedical Science, University of Sassari, Sassari, Italy., McKinney E; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK., Baxter EJ; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Gerstung M; Division of AI in Oncology, German Cancer Research Centre DKFZ, Heidelberg, Germany., Mitchell J; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wiseman D; Cancer Research UK, Manchester Institute, Manchester, UK., Bick AG; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Fabre M; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Quiros PM; Department of Biochemistry and Molecular Biology, Instituto Universitario de Oncología (IUOPA),Universidad de Oviedo, Oviedo, Spain., Nangalia J; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Kar S; Department of Oncology, Early Cancer Institute, University of Cambridge, Cambridge, UK., Vassiliou GS; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. gsv20@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK. gsv20@cam.ac.uk.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK. gsv20@cam.ac.uk.; Centre for the Study of Haematological Malignancies, Nicosia, Cyprus. gsv20@cam.ac.uk.; Cyprus Cancer Research Institute, Nicosia, Cyprus. gsv20@cam.ac.uk. |
| Source: | Nature genetics [Nat Genet] 2025 Sep; Vol. 57 (9), pp. 2215-2225. Date of Electronic Publication: 2025 Aug 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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