MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines.
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| Title: | MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines. |
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| Authors: | Amini A; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Garner LC; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Shaw RH; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Kelly NW; St Vincent's University Hospital and University College Dublin, Dublin, Ireland., Adele S; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Skelly DT; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Dejnirattisai W; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Division of Emerging Infectious Disease, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700, Thailand., Greenland M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Liu X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Heslington A; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK., Hackstein CP; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Center for Infection Prevention, Technical University of Munich, Munich, Germany., Murray SM; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Vano CR; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK., Stafford L; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Johnson S; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Sayaf K; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pudjohartono MF; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Bibi S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Conlon CP; Nuffield Department of Medicine, University of Oxford, Oxford, UK., James T; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Jeffery K; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Kronsteiner B; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Mentzer AJ; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., O'Shea D; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland., Ramasamy MN; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Screaton GR; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Snape MD; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Hogan AE; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland.; National Children's Research Centre, Dublin, Ireland., Barnes E; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Lambe T; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Dunachie SJ; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Provine NM; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Klenerman P; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. |
| Corporate Authors: | PITCH Consortium‡, Com-COV Study Group‡, PITCH Consortium, Com-COV Study Group |
| Source: | Science immunology [Sci Immunol] 2025 Aug 29; Vol. 10 (110), pp. eadu3337. Date of Electronic Publication: 2025 Aug 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.adu3337 |
