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MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines.

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Title: MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines.
Authors: Amini A; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Garner LC; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Shaw RH; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Kelly NW; St Vincent's University Hospital and University College Dublin, Dublin, Ireland., Adele S; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Skelly DT; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Dejnirattisai W; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Division of Emerging Infectious Disease, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700, Thailand., Greenland M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Liu X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Heslington A; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK., Hackstein CP; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Center for Infection Prevention, Technical University of Munich, Munich, Germany., Murray SM; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Vano CR; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK., Stafford L; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Johnson S; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Sayaf K; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pudjohartono MF; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Bibi S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Conlon CP; Nuffield Department of Medicine, University of Oxford, Oxford, UK., James T; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Jeffery K; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Kronsteiner B; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Mentzer AJ; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., O'Shea D; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland., Ramasamy MN; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Screaton GR; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Snape MD; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Hogan AE; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland.; National Children's Research Centre, Dublin, Ireland., Barnes E; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Lambe T; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Dunachie SJ; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Provine NM; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Klenerman P; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Corporate Authors: PITCH Consortium‡, Com-COV Study Group‡, PITCH Consortium, Com-COV Study Group
Source: Science immunology [Sci Immunol] 2025 Aug 29; Vol. 10 (110), pp. eadu3337. Date of Electronic Publication: 2025 Aug 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines.
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  Data: <searchLink fieldCode="AU" term="%22Amini+A%22">Amini A</searchLink>; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Garner+LC%22">Garner LC</searchLink>; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Shaw+RH%22">Shaw RH</searchLink>; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kelly+NW%22">Kelly NW</searchLink>; St Vincent's University Hospital and University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Adele+S%22">Adele S</searchLink>; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Skelly+DT%22">Skelly DT</searchLink>; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dejnirattisai+W%22">Dejnirattisai W</searchLink>; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Division of Emerging Infectious Disease, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700, Thailand.<br /><searchLink fieldCode="AU" term="%22Greenland+M%22">Greenland M</searchLink>; 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Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Stafford+L%22">Stafford L</searchLink>; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Johnson+S%22">Johnson S</searchLink>; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sayaf+K%22">Sayaf K</searchLink>; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pudjohartono+MF%22">Pudjohartono MF</searchLink>; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; 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Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Snape+MD%22">Snape MD</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hogan+AE%22">Hogan AE</searchLink>; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland.; National Children's Research Centre, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Barnes+E%22">Barnes E</searchLink>; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lambe+T%22">Lambe T</searchLink>; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dunachie+SJ%22">Dunachie SJ</searchLink>; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Provine+NM%22">Provine NM</searchLink>; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK.; 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