Randomized, double-blind, phase III LEAP-003 study of first-line lenvatinib plus pembrolizumab versus placebo plus pembrolizumab for unresectable or metastatic melanoma.

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Title: Randomized, double-blind, phase III LEAP-003 study of first-line lenvatinib plus pembrolizumab versus placebo plus pembrolizumab for unresectable or metastatic melanoma.
Authors: Arance A; Department of Medical Oncology, Hospital Clínic Barcelona and Translational Genomics and Targeted Therapies in Solid Tumours Research Group (IDIBAPS), Barcelona, Spain. Electronic address: amarance@clinic.cat., Berciano-Guerrero MA; Department of Medical Oncology, Hospital Regional Universitario (HRU), Instituto de Investigaciones Biomédicas de Málaga-Plataforma BIONAND (IBIMA-BioNAND), Málaga, Spain., Guo J; Department of Melanoma and Renal Cancer, Beijing University Cancer Hospital, Beijing, China., Carlino MS; Melanoma Institute Australia, Westmead and Blacktown Hospitals, University of Sydney, Sydney, Australia., Ascierto PA; Department of Skin Cancers, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione G Pascale, Naples, Italy., Burotto M; Centro de Investigación Clínica Bradford Hill, Santiago, Chile., Mortier L; Department of Dermatology, Université Lille, CHRU Lille, INSERM U1189, Lille, France., Queirolo P; Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, European Institute of Oncology (IEO), IRCCS, Milan, Italy., Chiarion-Sileni V; Melanoma Oncology Unit, Istituto Oncologico Veneto, IOV-IRCCS, Padova, Italy., Schachter J; Oncology Division, Sheba Medical Center, Tel HaShomer Hospital, Ramat Gan, Israel., Zhang X; Department of Medical Oncology, Sun Yat-sen University Cancer Centre, Guangzhou, China., Martin-Liberal J; Instituto Català d'Oncologia (ICO)-Hospital Duran i Reynals, Barcelona, Spain., Del Vecchio M; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Okpara CE; Eisai Ltd., Hatfield, UK., Dutcus C; Eisai Inc., Nutley, NJ, USA., Zhang J; Merck & Co. Inc., Rahway, NJ, USA., Diede SJ; Merck & Co. Inc., Rahway, NJ, USA., Neff T; Merck & Co. Inc., Rahway, NJ, USA., Long GV; Melanoma Institute Australia, University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, Australia.
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2025 Dec; Vol. 36 (12), pp. 1535-1546. Date of Electronic Publication: 2025 Aug 28.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1569-8041
DOI:10.1016/j.annonc.2025.08.008