Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT).
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| Title: | Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT). |
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| Authors: | Gagnon DJ; Department of Pharmacy, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA. Electronic address: David.Gagnon@mainehealth.org., Burkholder KM; School of Biological Sciences, University of New England, Biddeford, ME., Weissman AJ; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA., Riker RR; Department of Critical Care Services, Maine Medical Center, Portland, ME; Tufts University School of Medicine, Boston, MA., Ryzhov S; MaineHealth Institute for Research, Scarborough, ME., May TL; Department of Critical Care Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA., DiPalazzo J; MaineHealth Institute for Research, Scarborough, ME., deKay JT; MaineHealth Institute for Research, Scarborough, ME., Knudsen L; MaineHealth Institute for Research, Scarborough, ME., Moore MW; Department of Critical Care Services, Maine Medical Center, Portland, ME; Tufts University School of Medicine, Boston, MA., Pozzessere NA; Department of Critical Care Services, Maine Medical Center, Portland, ME., Weatherbee M; MaineHealth Institute for Research, Scarborough, ME., Kelly M; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Nigatu AS; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Sevigny JL; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Simpson S; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Thomas WK; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Callaway CW; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA., Geller BJ; Department of Cardiovascular Services, Maine Medical Center, Portland, ME., Sawyer DB; Department of Cardiovascular Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA., Seder DB; Department of Critical Care Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA. |
| Source: | Chest [Chest] 2026 Jan; Vol. 169 (1), pp. 115-127. Date of Electronic Publication: 2025 Aug 28. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 0231335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-3543 (Electronic) Linking ISSN: 00123692 NLM ISO Abbreviation: Chest Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40885534 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Gagnon+DJ%22">Gagnon DJ</searchLink>; Department of Pharmacy, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA. Electronic address: David.Gagnon@mainehealth.org.<br /><searchLink fieldCode="AU" term="%22Burkholder+KM%22">Burkholder KM</searchLink>; School of Biological Sciences, University of New England, Biddeford, ME.<br /><searchLink fieldCode="AU" term="%22Weissman+AJ%22">Weissman AJ</searchLink>; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Riker+RR%22">Riker RR</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME; Tufts University School of Medicine, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Ryzhov+S%22">Ryzhov S</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22May+TL%22">May TL</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA.<br /><searchLink fieldCode="AU" term="%22DiPalazzo+J%22">DiPalazzo J</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22deKay+JT%22">deKay JT</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22Knudsen+L%22">Knudsen L</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22Moore+MW%22">Moore MW</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME; Tufts University School of Medicine, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Pozzessere+NA%22">Pozzessere NA</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME.<br /><searchLink fieldCode="AU" term="%22Weatherbee+M%22">Weatherbee M</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22Kelly+M%22">Kelly M</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Nigatu+AS%22">Nigatu AS</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Sevigny+JL%22">Sevigny JL</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Simpson+S%22">Simpson S</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Thomas+WK%22">Thomas WK</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Callaway+CW%22">Callaway CW</searchLink>; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Geller+BJ%22">Geller BJ</searchLink>; Department of Cardiovascular Services, Maine Medical Center, Portland, ME.<br /><searchLink fieldCode="AU" term="%22Sawyer+DB%22">Sawyer DB</searchLink>; Department of Cardiovascular Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Seder+DB%22">Seder DB</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220231335%22">Chest</searchLink> [Chest] 2026 Jan; Vol. 169 (1), pp. 115-127. <i>Date of Electronic Publication: </i>2025 Aug 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0231335 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1931-3543 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200123692%22">00123692 </searchLink><i>NLM ISO Abbreviation: </i>Chest <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40885534 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.chest.2025.08.007 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 115 Titles: – TitleFull: Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gagnon DJ – PersonEntity: Name: NameFull: Burkholder KM – PersonEntity: Name: NameFull: Weissman AJ – PersonEntity: Name: NameFull: Riker RR – PersonEntity: Name: NameFull: Ryzhov S – PersonEntity: Name: NameFull: May TL – PersonEntity: Name: NameFull: DiPalazzo J – PersonEntity: Name: NameFull: deKay JT – PersonEntity: Name: NameFull: Knudsen L – PersonEntity: Name: NameFull: Moore MW – PersonEntity: Name: NameFull: Pozzessere NA – PersonEntity: Name: NameFull: Weatherbee M – PersonEntity: Name: NameFull: Kelly M – PersonEntity: Name: NameFull: Nigatu AS – PersonEntity: Name: NameFull: Sevigny JL – PersonEntity: Name: NameFull: Simpson S – PersonEntity: Name: NameFull: Thomas WK – PersonEntity: Name: NameFull: Callaway CW – PersonEntity: Name: NameFull: Geller BJ – PersonEntity: Name: NameFull: Sawyer DB – PersonEntity: Name: NameFull: Seder DB IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1931-3543 Numbering: – Type: volume Value: 169 – Type: issue Value: 1 Titles: – TitleFull: Chest Type: main |
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