Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT).

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Title: Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT).
Authors: Gagnon DJ; Department of Pharmacy, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA. Electronic address: David.Gagnon@mainehealth.org., Burkholder KM; School of Biological Sciences, University of New England, Biddeford, ME., Weissman AJ; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA., Riker RR; Department of Critical Care Services, Maine Medical Center, Portland, ME; Tufts University School of Medicine, Boston, MA., Ryzhov S; MaineHealth Institute for Research, Scarborough, ME., May TL; Department of Critical Care Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA., DiPalazzo J; MaineHealth Institute for Research, Scarborough, ME., deKay JT; MaineHealth Institute for Research, Scarborough, ME., Knudsen L; MaineHealth Institute for Research, Scarborough, ME., Moore MW; Department of Critical Care Services, Maine Medical Center, Portland, ME; Tufts University School of Medicine, Boston, MA., Pozzessere NA; Department of Critical Care Services, Maine Medical Center, Portland, ME., Weatherbee M; MaineHealth Institute for Research, Scarborough, ME., Kelly M; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Nigatu AS; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Sevigny JL; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Simpson S; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Thomas WK; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH., Callaway CW; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA., Geller BJ; Department of Cardiovascular Services, Maine Medical Center, Portland, ME., Sawyer DB; Department of Cardiovascular Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA., Seder DB; Department of Critical Care Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA.
Source: Chest [Chest] 2026 Jan; Vol. 169 (1), pp. 115-127. Date of Electronic Publication: 2025 Aug 28.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0231335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-3543 (Electronic) Linking ISSN: 00123692 NLM ISO Abbreviation: Chest Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gagnon+DJ%22">Gagnon DJ</searchLink>; Department of Pharmacy, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA. Electronic address: David.Gagnon@mainehealth.org.<br /><searchLink fieldCode="AU" term="%22Burkholder+KM%22">Burkholder KM</searchLink>; School of Biological Sciences, University of New England, Biddeford, ME.<br /><searchLink fieldCode="AU" term="%22Weissman+AJ%22">Weissman AJ</searchLink>; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Riker+RR%22">Riker RR</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME; Tufts University School of Medicine, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Ryzhov+S%22">Ryzhov S</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22May+TL%22">May TL</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA.<br /><searchLink fieldCode="AU" term="%22DiPalazzo+J%22">DiPalazzo J</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22deKay+JT%22">deKay JT</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22Knudsen+L%22">Knudsen L</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22Moore+MW%22">Moore MW</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME; Tufts University School of Medicine, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Pozzessere+NA%22">Pozzessere NA</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME.<br /><searchLink fieldCode="AU" term="%22Weatherbee+M%22">Weatherbee M</searchLink>; MaineHealth Institute for Research, Scarborough, ME.<br /><searchLink fieldCode="AU" term="%22Kelly+M%22">Kelly M</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Nigatu+AS%22">Nigatu AS</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Sevigny+JL%22">Sevigny JL</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Simpson+S%22">Simpson S</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Thomas+WK%22">Thomas WK</searchLink>; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH.<br /><searchLink fieldCode="AU" term="%22Callaway+CW%22">Callaway CW</searchLink>; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Geller+BJ%22">Geller BJ</searchLink>; Department of Cardiovascular Services, Maine Medical Center, Portland, ME.<br /><searchLink fieldCode="AU" term="%22Sawyer+DB%22">Sawyer DB</searchLink>; Department of Cardiovascular Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Seder+DB%22">Seder DB</searchLink>; Department of Critical Care Services, Maine Medical Center, Portland, ME; MaineHealth Institute for Research, Scarborough, ME; Tufts University School of Medicine, Boston, MA.
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  Data: <searchLink fieldCode="JN" term="%220231335%22">Chest</searchLink> [Chest] 2026 Jan; Vol. 169 (1), pp. 115-127. <i>Date of Electronic Publication: </i>2025 Aug 28.
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