Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice.
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| Title: | Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice. |
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| Authors: | Mohaqiq M; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Palou R; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, M5G 0A4, Canada., Li R; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Zhang G; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Vaishnav H; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Parweez F; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Moyana T; The Ottawa Hospital IBD center, Ottawa, ON, K1H 8L6, Canada., Carragher D; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Cameron DW; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Ramsay T; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., van der Sloot AM; The Quebec AI Institute, Mila, Montreal, QC, H2S 3H1, Canada., Murthy S; The Ottawa Hospital IBD center, Ottawa, ON, K1H 8L6, Canada., Coombes BK; McMaster University, Hamilton, ON, L8S 4K1, Canada., Tyers M; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, M5G 0A4, Canada. mike.tyers@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Canada. mike.tyers@sickkids.ca., Liu XJ; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jliu@ohri.ca.; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada. jliu@ohri.ca. |
| Source: | Scientific reports [Sci Rep] 2025 Aug 30; Vol. 15 (1), pp. 31959. Date of Electronic Publication: 2025 Aug 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-025-16736-5 |
