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Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice.

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Title: Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice.
Authors: Mohaqiq M; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Palou R; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, M5G 0A4, Canada., Li R; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Zhang G; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Vaishnav H; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Parweez F; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Moyana T; The Ottawa Hospital IBD center, Ottawa, ON, K1H 8L6, Canada., Carragher D; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Cameron DW; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Ramsay T; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., van der Sloot AM; The Quebec AI Institute, Mila, Montreal, QC, H2S 3H1, Canada., Murthy S; The Ottawa Hospital IBD center, Ottawa, ON, K1H 8L6, Canada., Coombes BK; McMaster University, Hamilton, ON, L8S 4K1, Canada., Tyers M; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, M5G 0A4, Canada. mike.tyers@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Canada. mike.tyers@sickkids.ca., Liu XJ; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jliu@ohri.ca.; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada. jliu@ohri.ca.
Source: Scientific reports [Sci Rep] 2025 Aug 30; Vol. 15 (1), pp. 31959. Date of Electronic Publication: 2025 Aug 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice.
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  Data: <searchLink fieldCode="AU" term="%22Mohaqiq+M%22">Mohaqiq M</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Palou+R%22">Palou R</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+G%22">Zhang G</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Vaishnav+H%22">Vaishnav H</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Parweez+F%22">Parweez F</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Moyana+T%22">Moyana T</searchLink>; The Ottawa Hospital IBD center, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Carragher+D%22">Carragher D</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Cameron+DW%22">Cameron DW</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Ramsay+T%22">Ramsay T</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22van+der+Sloot+AM%22">van der Sloot AM</searchLink>; The Quebec AI Institute, Mila, Montreal, QC, H2S 3H1, Canada.<br /><searchLink fieldCode="AU" term="%22Murthy+S%22">Murthy S</searchLink>; The Ottawa Hospital IBD center, Ottawa, ON, K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Coombes+BK%22">Coombes BK</searchLink>; McMaster University, Hamilton, ON, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Tyers+M%22">Tyers M</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, M5G 0A4, Canada. mike.tyers@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Canada. mike.tyers@sickkids.ca.<br /><searchLink fieldCode="AU" term="%22Liu+XJ%22">Liu XJ</searchLink>; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jliu@ohri.ca.; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada. jliu@ohri.ca.
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