Loss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP.

Saved in:
Bibliographic Details
Title: Loss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP.
Authors: Li X; Furong Laboratory, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, P. R. China.; Hunan Key Laboratory of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China.; Hunan Key Laboratory of Medical Genetics, Changsha, 410078, Hunan, P. R. China.; Hunan International Scientific and Technological Cooperation Base of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China.; MOE Key Laboratory of Rare Pediatric Diseases, Changsha, 410078, Hunan, P. R. China., Bader I; Furong Laboratory, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, P. R. China.; Hunan Key Laboratory of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China., Li X; Furong Laboratory, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, P. R. China.; Hunan Key Laboratory of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China.; Hunan Key Laboratory of Medical Genetics, Changsha, 410078, Hunan, P. R. China.; Hunan International Scientific and Technological Cooperation Base of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China.; MOE Key Laboratory of Rare Pediatric Diseases, Changsha, 410078, Hunan, P. R. China., Lu R; Furong Laboratory, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, P. R. China., Liu D; Furong Laboratory, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, P. R. China.; Hunan Key Laboratory of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China.; Hunan Key Laboratory of Medical Genetics, Changsha, 410078, Hunan, P. R. China.; Hunan International Scientific and Technological Cooperation Base of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China.; MOE Key Laboratory of Rare Pediatric Diseases, Changsha, 410078, Hunan, P. R. China., Chen Z; Department of Pediatrics, the Third Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Deng S; Furong Laboratory, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, P. R. China.; Hunan Key Laboratory of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China.; Hunan Key Laboratory of Medical Genetics, Changsha, 410078, Hunan, P. R. China.; Hunan International Scientific and Technological Cooperation Base of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China.; MOE Key Laboratory of Rare Pediatric Diseases, Changsha, 410078, Hunan, P. R. China., Shu Y; Department of Neurosurgery, Jinshan Hospital, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institute for Translational Brain Research, Fudan University, Shanghai, 200032, China., Liu H; MOE Key Laboratory of Rare Pediatric Diseases, Changsha, 410078, Hunan, P. R. China. huadie.liu@usc.edu.cn.; Department of Cell Biology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, P. R. China. huadie.liu@usc.edu.cn., Zhang J; Department of Laboratory Animals, Central South University, Changsha, Hunan, China. jingzhang@csu.edu.cn., Li JD; Furong Laboratory, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, P. R. China. lijiada@sklmg.edu.cn.; Hunan Key Laboratory of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China. lijiada@sklmg.edu.cn.; Hunan Key Laboratory of Medical Genetics, Changsha, 410078, Hunan, P. R. China. lijiada@sklmg.edu.cn.; Hunan International Scientific and Technological Cooperation Base of Animal Models for Human Diseases, Changsha, 410078, Hunan, P. R. China. lijiada@sklmg.edu.cn.; MOE Key Laboratory of Rare Pediatric Diseases, Changsha, 410078, Hunan, P. R. China. lijiada@sklmg.edu.cn.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Feb; Vol. 31 (2), pp. 895-907. Date of Electronic Publication: 2025 Aug 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03187-7