REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3-CD38 axis.

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Title: REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3-CD38 axis.
Authors: Lee J; Department of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. jylee8764@gmail.com.; Center for Convergence Research of Neurological Disorders, Ajou University School of Medicine, Suwon, South Korea. jylee8764@gmail.com., Kang R; Department of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Park S; Department of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Saliu IO; Department of Genetics and Department of Neurology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA., Son M; Department of Biochemistry and Molecular Biophysics, Mass Spectrometry Technology Access Center (MTAC), Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA., Voorhees JR; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA., Dimitry JM; Department of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Quillin EI; Department of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Woodie LN; Institute for Diabetes, Obesity, and Metabolism and Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lananna BV; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA., Gan L; Helen and Robert Appel Alzheimer Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA., Goo YA; Department of Biochemistry and Molecular Biophysics, Mass Spectrometry Technology Access Center (MTAC), Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA., Zhao G; Department of Genetics and Department of Neurology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA., Lazar MA; Institute for Diabetes, Obesity, and Metabolism and Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Burris TP; UF Genetics Institute and Department Of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Musiek ES; Department of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. musieke@wustl.edu.
Source: Nature aging [Nat Aging] 2025 Oct; Vol. 5 (10), pp. 2070-2085. Date of Electronic Publication: 2025 Sep 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-8465
DOI:10.1038/s43587-025-00950-x