Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine.

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Title: Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine.
Authors: Glazer AM; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA., Tabet DR; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada., Parikh VN; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Kroncke BM; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA., Cote AG; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada., Yamamoto Y; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Wang Q; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Muhammad A; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA., Lancaster MC; Department of Medicine (Cardiovascular Medicine), The Ohio State University, Columbus, OH, USA., O'Neill MJ; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA.; Brigham and Women's Hospital, Boston, MA, USA., Weile J; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada., Yang T; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA., Macrae CA; Brigham and Women's Hospital, Boston, MA, USA., Ashley EA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Roth FP; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada.; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Roden DM; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA. dan.roden@vumc.org.; Department of Pharmacology and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. dan.roden@vumc.org.
Source: Nature reviews. Cardiology [Nat Rev Cardiol] 2026 Mar; Vol. 23 (3), pp. 149-163. Date of Electronic Publication: 2025 Sep 01.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-5010 (Electronic) Linking ISSN: 17595002 NLM ISO Abbreviation: Nat Rev Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1759-5010
DOI:10.1038/s41569-025-01201-7