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Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine.

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Title: Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine.
Authors: Glazer AM; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA., Tabet DR; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada., Parikh VN; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Kroncke BM; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA., Cote AG; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada., Yamamoto Y; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Wang Q; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Muhammad A; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA., Lancaster MC; Department of Medicine (Cardiovascular Medicine), The Ohio State University, Columbus, OH, USA., O'Neill MJ; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA.; Brigham and Women's Hospital, Boston, MA, USA., Weile J; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada., Yang T; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA., Macrae CA; Brigham and Women's Hospital, Boston, MA, USA., Ashley EA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Roth FP; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada.; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Roden DM; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA. dan.roden@vumc.org.; Department of Pharmacology and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. dan.roden@vumc.org.
Source: Nature reviews. Cardiology [Nat Rev Cardiol] 2026 Mar; Vol. 23 (3), pp. 149-163. Date of Electronic Publication: 2025 Sep 01.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-5010 (Electronic) Linking ISSN: 17595002 NLM ISO Abbreviation: Nat Rev Cardiol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Glazer+AM%22">Glazer AM</searchLink>; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Tabet+DR%22">Tabet DR</searchLink>; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Parikh+VN%22">Parikh VN</searchLink>; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kroncke+BM%22">Kroncke BM</searchLink>; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cote+AG%22">Cote AG</searchLink>; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Yamamoto+Y%22">Yamamoto Y</searchLink>; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Muhammad+A%22">Muhammad A</searchLink>; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lancaster+MC%22">Lancaster MC</searchLink>; Department of Medicine (Cardiovascular Medicine), The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22O'Neill+MJ%22">O'Neill MJ</searchLink>; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA.; Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weile+J%22">Weile J</searchLink>; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Macrae+CA%22">Macrae CA</searchLink>; Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ashley+EA%22">Ashley EA</searchLink>; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Roth+FP%22">Roth FP</searchLink>; Donnelly Centre; Department of Molecular Genetics; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada.; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Department of Medicine (Genetic Medicine and Clinical Pharmacology), Vanderbilt University Medical Center, Nashville, TN, USA. dan.roden@vumc.org.; Department of Pharmacology and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. dan.roden@vumc.org.
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  Data: <searchLink fieldCode="JN" term="%22101500075%22">Nature reviews. Cardiology</searchLink> [Nat Rev Cardiol] 2026 Mar; Vol. 23 (3), pp. 149-163. <i>Date of Electronic Publication: </i>2025 Sep 01.
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