Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals.
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| Title: | Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals. |
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| Authors: | Saini M; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States., Aschenbrenner JC; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., Ruiz FX; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States., Chopra A; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States., Chandran AV; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., Marples PG; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., Balcomb BH; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., Fearon D; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., von Delft F; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K.; Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, Headington, Oxford OX3 7FZ, U.K., Arnold E; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2025 Sep 11; Vol. 68 (17), pp. 18356-18369. Date of Electronic Publication: 2025 Sep 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40892049 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Saini+M%22">Saini M</searchLink>; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.<br /><searchLink fieldCode="AU" term="%22Aschenbrenner+JC%22">Aschenbrenner JC</searchLink>; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K.<br /><searchLink fieldCode="AU" term="%22Ruiz+FX%22">Ruiz FX</searchLink>; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.<br /><searchLink fieldCode="AU" term="%22Chopra+A%22">Chopra A</searchLink>; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.<br /><searchLink fieldCode="AU" term="%22Chandran+AV%22">Chandran AV</searchLink>; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K.<br /><searchLink fieldCode="AU" term="%22Marples+PG%22">Marples PG</searchLink>; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K.<br /><searchLink fieldCode="AU" term="%22Balcomb+BH%22">Balcomb BH</searchLink>; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K.<br /><searchLink fieldCode="AU" term="%22Fearon+D%22">Fearon D</searchLink>; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K.<br /><searchLink fieldCode="AU" term="%22von+Delft+F%22">von Delft F</searchLink>; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K.; Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, Headington, Oxford OX3 7FZ, U.K.<br /><searchLink fieldCode="AU" term="%22Arnold+E%22">Arnold E</searchLink>; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Sep 11; Vol. 68 (17), pp. 18356-18369. <i>Date of Electronic Publication: </i>2025 Sep 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40892049 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.5c01014 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 18356 Titles: – TitleFull: Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Saini M – PersonEntity: Name: NameFull: Aschenbrenner JC – PersonEntity: Name: NameFull: Ruiz FX – PersonEntity: Name: NameFull: Chopra A – PersonEntity: Name: NameFull: Chandran AV – PersonEntity: Name: NameFull: Marples PG – PersonEntity: Name: NameFull: Balcomb BH – PersonEntity: Name: NameFull: Fearon D – PersonEntity: Name: NameFull: von Delft F – PersonEntity: Name: NameFull: Arnold E IsPartOfRelationships: – BibEntity: Dates: – D: 11 M: 09 Text: 2025 Sep 11 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 68 – Type: issue Value: 17 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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