Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals.
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| Title: | Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals. |
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| Authors: | Saini M; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States., Aschenbrenner JC; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., Ruiz FX; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States., Chopra A; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States., Chandran AV; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., Marples PG; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., Balcomb BH; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., Fearon D; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K., von Delft F; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, U.K.; Research Complex at Harwell, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0FA, U.K.; Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, Headington, Oxford OX3 7FZ, U.K., Arnold E; Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.; Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2025 Sep 11; Vol. 68 (17), pp. 18356-18369. Date of Electronic Publication: 2025 Sep 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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