Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.

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Title: Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.
Authors: Wilhelmsen K; BioAge Labs , Emeryville, CA, USA., Deshpande A; BioAge Labs , Emeryville, CA, USA., Tronnes S; BioAge Labs , Emeryville, CA, USA., Mahanta M; BioAge Labs , Emeryville, CA, USA., Banicki M; BioAge Labs , Emeryville, CA, USA., Cochran M; BioAge Labs , Emeryville, CA, USA., Cowdin S; BioAge Labs , Emeryville, CA, USA., Fortney K; BioAge Labs , Emeryville, CA, USA., Hartman G; BioAge Labs , Emeryville, CA, USA., Hughes RE; BioAge Labs , Emeryville, CA, USA., Montgomery R; BioAge Labs , Emeryville, CA, USA., Portillo CP; BioAge Labs , Emeryville, CA, USA., Rubin P; BioAge Labs , Emeryville, CA, USA., Salazar T; BioAge Labs , Emeryville, CA, USA., Wang Y; BioAge Labs , Emeryville, CA, USA., Yan S; BioAge Labs , Emeryville, CA, USA., Morgan BA; HitGen Pharmaceuticals Inc. , Houston, TX, USA., Duisembekova A; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon , Lyon, France., Riou R; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon , Lyon, France., Marleaux M; Institute of Structural Biology, University of Bonn , Bonn, Germany., Hochheiser IV; Institute of Structural Biology, University of Bonn , Bonn, Germany., Buthmann H; Institute of Structural Biology, University of Bonn , Bonn, Germany., Ferber D; Institute of Structural Biology, University of Bonn , Bonn, Germany., Torp J; Institute of Structural Biology, University of Bonn , Bonn, Germany., Wang W; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., Cranston M; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., McKee CM; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., Mawhinney TJ; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., McKay EC; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., Eroglu FK; Department of Innate Immunity, Institute of Immunology, Tübingen, Germany.; Department of Pediatrics I, Pediatric Rheumatology and Autoinflammation Reference Center, University Hospital Tübingen, Tübingen, Germany., Kümmerle-Deschner J; Department of Pediatrics I, Pediatric Rheumatology and Autoinflammation Reference Center, University Hospital Tübingen, Tübingen, Germany., Weber ANR; Department of Innate Immunity, Institute of Immunology, Tübingen, Germany.; Cluster of Excellence 2180 'Image-guided and Functionally Instructed Tumor Therapies' and Cluster of Excellence 2124 'Controlling Microbes to Fight Infection', University of Tübingen , Tübingen, Germany., Py BF; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon , Lyon, France., Geyer M; Institute of Structural Biology, University of Bonn , Bonn, Germany., Coll RC; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK.
Source: The Journal of experimental medicine [J Exp Med] 2025 Nov 03; Vol. 222 (11). Date of Electronic Publication: 2025 Sep 02.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1540-9538
DOI:10.1084/jem.20242403