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Efficacy and Safety of a Novel Triple Single-Pill for Uncontrolled Hypertension: The OPTION TREAT Trial.

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Title: Efficacy and Safety of a Novel Triple Single-Pill for Uncontrolled Hypertension: The OPTION TREAT Trial.
Authors: Madrini V Jr; Hospital Israelita Albert Einstein, São Paulo, Brazil., Tavares CAM; Hospital Israelita Albert Einstein, São Paulo, Brazil; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Albuquerque MTA; Hospital Israelita Albert Einstein, São Paulo, Brazil., Silvestre OM; Universidade Federal do Acre, Rio Branco, Brazil., Felicio JS; João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Silveira FS; Centro de Pesquisa Clínica do Coração, Aracaju, Brazil., Hissa MN; Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas/Clínica Popular Endocrinologia, Fortaleza, Brazil., Antunes MO; Hospital Universitário São Francisco de Assis na Providência de Deus da Universidade de São Francisco, Bragança Paulista, Brazil., Mota-Gomes MA; Centro Universitário CESMAC, Maceió, Brazil., Vidotti MH; Centro I9 Pesquisa Clínica, Campinas, Brazil., Fuchs FD; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Marcondes-Braga FG; Centro, CIPES, São José dos Campos, Brazil., Filho CRH; W&H Cardiologia, Joinville, Brazil., Troiani do Nascimento C; Hospital Regional de Presidente Prudente, Presidente Prudente, Brazil., Bastos RA; Centro Ruy Azeredo, Goiânia, Brazil., Brandão AA; Faculdade de Ciências Médicas-Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Cestário EES; Clínica Cardiológica, Votuporanga, Brazil., Bortolotto LA; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Castilho VC; Libbs Pharmaceuticals, São Paulo, Brazil., Lapa MG; Libbs Pharmaceuticals, São Paulo, Brazil., Magaton EAP; Libbs Pharmaceuticals, São Paulo, Brazil., Fernandes PB; Libbs Pharmaceuticals, São Paulo, Brazil., Albuquerque CSN; Hospital Israelita Albert Einstein, São Paulo, Brazil., Silva LR; Hospital Israelita Albert Einstein, São Paulo, Brazil., Berwanger O; George Institute for Global Health UK, London, United Kingdom; Imperial College London, London, United Kingdom., Guimarães PO; Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address: patricia.oguimaraes@einstein.br.
Source: JACC. Advances [JACC Adv] 2025 Oct; Vol. 4 (10 Pt 2), pp. 102175. Date of Electronic Publication: 2025 Aug 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918419284106676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-963X (Electronic) Linking ISSN: 2772963X NLM ISO Abbreviation: JACC Adv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and Safety of a Novel Triple Single-Pill for Uncontrolled Hypertension: The OPTION TREAT Trial.
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  Data: <searchLink fieldCode="AU" term="%22Madrini+V+Jr%22">Madrini V Jr</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Tavares+CAM%22">Tavares CAM</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Albuquerque+MTA%22">Albuquerque MTA</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Silvestre+OM%22">Silvestre OM</searchLink>; Universidade Federal do Acre, Rio Branco, Brazil.<br /><searchLink fieldCode="AU" term="%22Felicio+JS%22">Felicio JS</searchLink>; João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil.<br /><searchLink fieldCode="AU" term="%22Silveira+FS%22">Silveira FS</searchLink>; Centro de Pesquisa Clínica do Coração, Aracaju, Brazil.<br /><searchLink fieldCode="AU" term="%22Hissa+MN%22">Hissa MN</searchLink>; Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas/Clínica Popular Endocrinologia, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Antunes+MO%22">Antunes MO</searchLink>; Hospital Universitário São Francisco de Assis na Providência de Deus da Universidade de São Francisco, Bragança Paulista, Brazil.<br /><searchLink fieldCode="AU" term="%22Mota-Gomes+MA%22">Mota-Gomes MA</searchLink>; Centro Universitário CESMAC, Maceió, Brazil.<br /><searchLink fieldCode="AU" term="%22Vidotti+MH%22">Vidotti MH</searchLink>; Centro I9 Pesquisa Clínica, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Fuchs+FD%22">Fuchs FD</searchLink>; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Marcondes-Braga+FG%22">Marcondes-Braga FG</searchLink>; Centro, CIPES, São José dos Campos, Brazil.<br /><searchLink fieldCode="AU" term="%22Filho+CRH%22">Filho CRH</searchLink>; W&H Cardiologia, Joinville, Brazil.<br /><searchLink fieldCode="AU" term="%22Troiani+do+Nascimento+C%22">Troiani do Nascimento C</searchLink>; Hospital Regional de Presidente Prudente, Presidente Prudente, Brazil.<br /><searchLink fieldCode="AU" term="%22Bastos+RA%22">Bastos RA</searchLink>; Centro Ruy Azeredo, Goiânia, Brazil.<br /><searchLink fieldCode="AU" term="%22Brandão+AA%22">Brandão AA</searchLink>; Faculdade de Ciências Médicas-Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Cestário+EES%22">Cestário EES</searchLink>; Clínica Cardiológica, Votuporanga, Brazil.<br /><searchLink fieldCode="AU" term="%22Bortolotto+LA%22">Bortolotto LA</searchLink>; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Castilho+VC%22">Castilho VC</searchLink>; Libbs Pharmaceuticals, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Lapa+MG%22">Lapa MG</searchLink>; Libbs Pharmaceuticals, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Magaton+EAP%22">Magaton EAP</searchLink>; Libbs Pharmaceuticals, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Fernandes+PB%22">Fernandes PB</searchLink>; Libbs Pharmaceuticals, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Albuquerque+CSN%22">Albuquerque CSN</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+LR%22">Silva LR</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Berwanger+O%22">Berwanger O</searchLink>; George Institute for Global Health UK, London, United Kingdom; Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Guimarães+PO%22">Guimarães PO</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address: patricia.oguimaraes@einstein.br.
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  Data: <searchLink fieldCode="JN" term="%229918419284106676%22">JACC. Advances</searchLink> [JACC Adv] 2025 Oct; Vol. 4 (10 Pt 2), pp. 102175. <i>Date of Electronic Publication: </i>2025 Aug 29.
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