HLA-B*15:01-positive severe COVID-19 patients lack CD8+ T cell pools with highly expanded public clonotypes.

Saved in:
Bibliographic Details
Title: HLA-B*15:01-positive severe COVID-19 patients lack CD8+ T cell pools with highly expanded public clonotypes.
Authors: Rowntree LC; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Allen LF; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Hagen RR; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., McQuilten HA; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Quadeer AA; Department of Electronic and Computer Engineering, School of Engineering, Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, Hong Kong, China.; Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, VIC 3010, Australia., Chaurasia P; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Kaewpreedee P; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Lee KWK; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Cohen CA; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Petersen J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Littler DR; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Habel JR; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Zhang W; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Cheng SMS; Division of Public Health Laboratory Sciences, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Chan KKP; Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Kwok JSY; Division of Transplantation and Immunogenetics, Department of Pathology, Queen Mary Hospital, Hong Kong Special Administrative Region, Hong Kong, China., Leung KSM; The Hong Kong Jockey Club Global Health Institute, Hong Kong Special Administrative Region, Hong Kong, China.; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; Laboratory of Data Discovery for Health, Hong Kong Science Park, Hong Kong Special Administrative Region, Hong Kong, China.; The University of Hong Kong - Shenzhen Hospital, Shenzhen 518009, China., Wu JT; The Hong Kong Jockey Club Global Health Institute, Hong Kong Special Administrative Region, Hong Kong, China.; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; Laboratory of Data Discovery for Health, Hong Kong Science Park, Hong Kong Special Administrative Region, Hong Kong, China.; The University of Hong Kong - Shenzhen Hospital, Shenzhen 518009, China., Lee CK; The Hong Kong Jockey Club Global Health Institute, Hong Kong Special Administrative Region, Hong Kong, China.; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; Laboratory of Data Discovery for Health, Hong Kong Science Park, Hong Kong Special Administrative Region, Hong Kong, China.; The University of Hong Kong - Shenzhen Hospital, Shenzhen 518009, China., Davies J; Menzies School of Health Research, Darwin, NT 0810, Australia., Pannaraj PS; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027.; Department of Pediatrics, Molecular Microbiology and Immunology, Keck School of Medicine, The University of California, Los Angeles, CA 90033., Kaity Allen E; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105., Tosif S; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia.; Department of General Medicine, Royal Children's Hospital Melbourne, Melbourne, VIC 3052, Australia., Crawford NW; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia.; Department of General Medicine, Royal Children's Hospital Melbourne, Melbourne, VIC 3052, Australia.; Royal Children's Hospital Melbourne, Immunisation Service, Melbourne, VIC 3052, Australia., Lappas M; Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC 3010, Australia., Thevarajan I; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Lewin SR; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, VIC 3004, Australia., Kent SJ; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC 3010, Australia.; Melbourne Sexual Health Centre, Infectious Diseases Department, Alfred Health, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia., Juno JA; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Bond KA; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Victorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Department of Microbiology, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia., Williamson DA; Victorian Infectious Diseases Service, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Victorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; School of Medicine, University of St Andrews, Scotland KY16 9TF, United Kingdom., Holmes NE; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC 3084, Australia.; Data Analytics Research and Evaluation Centre, Austin Health and University of Melbourne, Heidelberg, VIC 3084, Australia.; Department of Infectious Diseases, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, VIC 3084, Australia., Smibert OC; Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC 3084, Australia.; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.; National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC 3000, Australia., Gordon CL; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC 3084, Australia., Trubiano JA; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Department of Infectious Diseases, Centre for Antibiotic Allergy and Research, Austin Health, Heidelberg, VIC 3084, Australia.; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.; National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC 3000, Australia., Kotsimbos TC; Department of Respiratory Medicine, The Alfred Hospital, Melbourne, VIC 3004, Australia.; Department of Medicine, Central Clinical School, The Alfred Hospital, Monash University, Melbourne, VIC 3004, Australia., Cheng AC; School of Public Health and Preventive Medicine, Monash University, Clayton, VIC 3004, Australia.; Monash Infectious Diseases, Monash Health and School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia., Efstathiou C; National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom., Turtle L; Institute of Infection, Ecological and Veterinary Sciences, University of Liverpool & Liverpool University Hospital National Health Service Foundation Trust, Wirral CH64 7TE, United Kingdom., Thwaites RS; National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom., Brightling CE; Institute for Lung Health, Leicester NIHR BRC, University of Leicester, Leicester LE1 7RH, United Kingdom., Rossjohn J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom., McKay MR; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Department of Electronic and Computer Engineering, School of Engineering, Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, Hong Kong, China.; Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, VIC 3010, Australia.; Victorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Tian J; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Liu WJ; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Gao GF; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Xu J; Shanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai 201508, China., Sonehara K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.; Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo 113-8654, Japan., Ishii KJ; Laboratory of Adjuvant Innovation, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Saito Asagi, Ibaraki 567-0085, Osaka, Japan.; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.; Department of Immunopathology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan., Namkoong H; Department of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan., Okada Y; Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo 113-8654, Japan.; Department of Immunopathology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Premium Research Institute for Human Metaverse Medicine, Osaka University, Suita 565-0871, Japan., Peiris M; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; Division of Public Health Laboratory Sciences, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; Centre for Immunology and Infection, Hong Kong Science and Technology Park, New Territories, Hong Kong Special Administrative Region, Hong Kong, China., Hui DSC; Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Poon LLM; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; Division of Public Health Laboratory Sciences, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; Centre for Immunology and Infection, Hong Kong Science and Technology Park, New Territories, Hong Kong Special Administrative Region, Hong Kong, China., Doherty PC; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Nguyen THO; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Valkenburg SA; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Kedzierska K; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; Institute for Vaccine Research and Development, Hokkaido University, Sapporo 001-0021, Japan.
Corporate Authors: PHOSP-COVID Collaborative Group
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Sep 09; Vol. 122 (36), pp. e2503145122. Date of Electronic Publication: 2025 Sep 02.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2503145122