Open-Label, Phase II Trial of Extracellular Regulated Kinase Inhibition Alone and in Combination With Autophagy Inhibition in Patients With Metastatic Pancreatic Cancer.

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Title: Open-Label, Phase II Trial of Extracellular Regulated Kinase Inhibition Alone and in Combination With Autophagy Inhibition in Patients With Metastatic Pancreatic Cancer.
Authors: Surana R; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Morgado M; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Somasundaram A; Division of Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., Bockorny B; Department of Medical Oncology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA., Weekes CD; Department of Medical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Coleman EC; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Bird A; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Wang J; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Williams HL; Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Zheng H; Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Brais LK; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Saxena N; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Graham C; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Ritterband L; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Sawin M; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Peters ML; Department of Medical Oncology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA., Whooley P; Department of Medical Oncology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA., Bullock A; Department of Medical Oncology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA., Zerillo J; Department of Medical Oncology, Beth Israel Deaconess Hospital and Harvard Medical School, Boston, MA., Sanoff HK; Division of Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., Clark JW; Department of Medical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Parikh AR; Department of Medical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Yurgelun MB; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Patel AK; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Mayer RJ; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Cleary JM; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Enzinger P; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Rubinson DA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., McCleary NJ; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Enzinger A; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Slater S; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Ng K; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Biller LH; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Abrams TA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Huffman BM; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Singh H; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Raghavan S; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Mancias JD; Department of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Bryant KL; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., Nowak JO; Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Der CJ; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Perez K; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.
Source: JCO precision oncology [JCO Precis Oncol] 2025 Sep; Vol. 9, pp. e2500332. Date of Electronic Publication: 2025 Sep 02.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101705370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2473-4284 (Electronic) Linking ISSN: 24734284 NLM ISO Abbreviation: JCO Precis Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2473-4284
DOI:10.1200/PO-25-00332