Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.

Saved in:
Bibliographic Details
Title: Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.
Authors: Min HK; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Zhao H; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China., Bahcheli A; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Pan P; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada.; Institute of Robotics and Intelligent Systems, Dalian University of Technology, Dalian, China., Chan J; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Chen J; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Low E; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Zhou Y; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada., Wang X; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Mechanical and Materials Engineering, Queen's University, Kingston, Ontario, Canada.; Ingenuity Labs Research Institute, Queen's University, Kingston, Ontario, Canada., Bajic S; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada., Peng R; College of Marine Engineering, Dalian Maritime University, Dalian, China., Wanggou S; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China., Yang Q; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Zhang RDY; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Wang L; Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China., Ren X; Department of Pathology, Shengjing Hospital, China Medical University, Shenyang, China., Qi H; Yu-Yue Pathology Scientific Research Center and Jinfeng Laboratory, Chongqing, China., Shi Y; Yu-Yue Pathology Scientific Research Center and Jinfeng Laboratory, Chongqing, China., Hayes MN; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Ciruna B; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Reimand J; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Liu X; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Huang X; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. xi.huang@sickkids.ca.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. xi.huang@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. xi.huang@sickkids.ca.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Mar; Vol. 10 (3), pp. 565-583. Date of Electronic Publication: 2025 Sep 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2157-846X
DOI:10.1038/s41551-025-01487-5