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Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.

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Title: Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.
Authors: Min HK; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Zhao H; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China., Bahcheli A; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Pan P; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada.; Institute of Robotics and Intelligent Systems, Dalian University of Technology, Dalian, China., Chan J; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Chen J; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Low E; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Zhou Y; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada., Wang X; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Mechanical and Materials Engineering, Queen's University, Kingston, Ontario, Canada.; Ingenuity Labs Research Institute, Queen's University, Kingston, Ontario, Canada., Bajic S; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada., Peng R; College of Marine Engineering, Dalian Maritime University, Dalian, China., Wanggou S; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China., Yang Q; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Zhang RDY; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Wang L; Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China., Ren X; Department of Pathology, Shengjing Hospital, China Medical University, Shenyang, China., Qi H; Yu-Yue Pathology Scientific Research Center and Jinfeng Laboratory, Chongqing, China., Shi Y; Yu-Yue Pathology Scientific Research Center and Jinfeng Laboratory, Chongqing, China., Hayes MN; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Ciruna B; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Reimand J; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Liu X; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Huang X; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. xi.huang@sickkids.ca.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. xi.huang@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. xi.huang@sickkids.ca.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Mar; Vol. 10 (3), pp. 565-583. Date of Electronic Publication: 2025 Sep 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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  Data: Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.
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  Data: <searchLink fieldCode="AU" term="%22Min+HK%22">Min HK</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Bahcheli+A%22">Bahcheli A</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pan+P%22">Pan P</searchLink>; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada.; Institute of Robotics and Intelligent Systems, Dalian University of Technology, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Chan+J%22">Chan J</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Low+E%22">Low E</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Mechanical and Materials Engineering, Queen's University, Kingston, Ontario, Canada.; Ingenuity Labs Research Institute, Queen's University, Kingston, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bajic+S%22">Bajic S</searchLink>; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Peng+R%22">Peng R</searchLink>; College of Marine Engineering, Dalian Maritime University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Wanggou+S%22">Wanggou S</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+RDY%22">Zhang RDY</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ren+X%22">Ren X</searchLink>; Department of Pathology, Shengjing Hospital, China Medical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Qi+H%22">Qi H</searchLink>; Yu-Yue Pathology Scientific Research Center and Jinfeng Laboratory, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Yu-Yue Pathology Scientific Research Center and Jinfeng Laboratory, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Hayes+MN%22">Hayes MN</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ciruna+B%22">Ciruna B</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Reimand+J%22">Reimand J</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. xi.huang@sickkids.ca.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. xi.huang@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. xi.huang@sickkids.ca.
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  Data: <searchLink fieldCode="JN" term="%22101696896%22">Nature biomedical engineering</searchLink> [Nat Biomed Eng] 2026 Mar; Vol. 10 (3), pp. 565-583. <i>Date of Electronic Publication: </i>2025 Sep 02.
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