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Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.

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Title: Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.
Authors: Hollander K; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT USA.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT USA., Devarkar SC; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT USA., Tang S; Department of Pharmacology, Yale University School of Medicine, New Haven, CT USA., Tiwari R; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MI USA., Ma S; Department of Pharmacology, Yale University School of Medicine, New Haven, CT USA., Lee WG; Department of Chemistry, Yale University, New Haven, CT USA., Denn E; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MI USA., Wang Q; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MI USA., Spasov KA; Department of Pharmacology, Yale University School of Medicine, New Haven, CT USA., Robbins JA; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT USA.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT USA., Frey KM; School of Pharmacy and Health Sciences, Fairleigh Dickinson University, Florham Park, NJ USA., Jorgensen WL; Department of Chemistry, Yale University, New Haven, CT USA., Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT USA., Shan L; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MI USA., Anderson KS; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT USA.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT USA.
Source: NPJ drug discovery [NPJ Drug Discov] 2025; Vol. 2 (1), pp. 22. Date of Electronic Publication: 2025 Sep 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918993695206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 3005-1452 (Electronic) Linking ISSN: 30051452 NLM ISO Abbreviation: NPJ Drug Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:3005-1452
DOI:10.1038/s44386-025-00025-2