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Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs-PKCε-insulin receptor kinaseT1150 pathway.

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Title: Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs-PKCε-insulin receptor kinaseT1150 pathway.
Authors: Zheng J; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Gaspar RC; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Sakuma I; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Molecular Diagnosis Graduate School of Medicine, Chiba University, Chiba, Japan., Hubbard BT; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA., Zhang D; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Nasiri A; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Kahn M; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Perelis M; Ionis Pharmaceuticals, Carlsbad, CA, USA., Samuel VT; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Petersen KF; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Shulman GI; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. gerald.shulman@yale.edu.; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA. gerald.shulman@yale.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. gerald.shulman@yale.edu.
Source: Diabetologia [Diabetologia] 2025 Dec; Vol. 68 (12), pp. 2906-2920. Date of Electronic Publication: 2025 Sep 04.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs-PKCε-insulin receptor kinase<superscript>T1150</superscript> pathway.
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  Data: <searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Gaspar+RC%22">Gaspar RC</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Sakuma+I%22">Sakuma I</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Molecular Diagnosis Graduate School of Medicine, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Hubbard+BT%22">Hubbard BT</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Nasiri+A%22">Nasiri A</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Kahn+M%22">Kahn M</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Perelis+M%22">Perelis M</searchLink>; Ionis Pharmaceuticals, Carlsbad, CA, USA.<br /><searchLink fieldCode="AU" term="%22Samuel+VT%22">Samuel VT</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Petersen+KF%22">Petersen KF</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Shulman+GI%22">Shulman GI</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. gerald.shulman@yale.edu.; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA. gerald.shulman@yale.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. gerald.shulman@yale.edu.
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  Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2025 Dec; Vol. 68 (12), pp. 2906-2920. <i>Date of Electronic Publication: </i>2025 Sep 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0006777 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0428 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220012186X%22">0012186X </searchLink><i>NLM ISO Abbreviation: </i>Diabetologia <i>Subsets: </i>MEDLINE
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              Text: 2025 Dec
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