A Multicenter, Open-Label Study to Assess the Safety of Nebulized Tissue Plasminogen Activator for the Acute Treatment of Pediatric Plastic Bronchitis: The PLATyPuS Trial.

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Title: A Multicenter, Open-Label Study to Assess the Safety of Nebulized Tissue Plasminogen Activator for the Acute Treatment of Pediatric Plastic Bronchitis: The PLATyPuS Trial.
Authors: Stringer KA; Department of Clinical Pharmacy and the NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA., Goldberg D; Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Chen S; Division of Pediatric Cardiology, Department of Pediatrics, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California, USA., Thrush P; Division of Pediatric Cardiology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Graham EM; Division of Pediatric Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, USA., Lubert A; Division of Pediatric Cardiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Myers J; Department of Pathology, Lung and Thoracic Pathology, University of Michigan Health System, Ann Arbor, Michigan, USA., McLellan L; Department of Clinical Pharmacy and the NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA., Flott T; Department of Clinical Pharmacy and the NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA., Nasr S; Division of Pediatric Pulmonology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, Michigan, USA., Schumacher KR; Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, Michigan, USA.
Source: Pharmacotherapy [Pharmacotherapy] 2025 Oct; Vol. 45 (10), pp. 677-687. Date of Electronic Publication: 2025 Sep 05.
Publication Type: Journal Article; Multicenter Study; Clinical Trial, Phase II
Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8111305 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9114 (Electronic) Linking ISSN: 02770008 NLM ISO Abbreviation: Pharmacotherapy Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1875-9114
DOI:10.1002/phar.70056