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9-fluorenone-based synthetic sulfonamide compounds as dual inhibitors of SARS-CoV-2 Main-Protease and Papain-like Protease.

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Title: 9-fluorenone-based synthetic sulfonamide compounds as dual inhibitors of SARS-CoV-2 Main-Protease and Papain-like Protease.
Authors: Das S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research- Indian Institute of Chemical Biology (CSIR-IICB), Jadavpur, Kolkata, 700032, India., Sunnapu P; Organic and Medicinal Chemistry Division, Laboratory of Catalysis and Chemical Biology, Council of Scientific and Industrial Research- Indian Institute of Chemical Biology (CSIR-IICB), Jadavpur, Kolkata, 700032, India., Rafi M; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Organic and Medicinal Chemistry Division, Laboratory of Catalysis and Chemical Biology, Council of Scientific and Industrial Research- Indian Institute of Chemical Biology (CSIR-IICB), Jadavpur, Kolkata, 700032, India., Begum Y; Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research- Indian Institute of Chemical Biology (CSIR-IICB), Jadavpur, Kolkata, 700032, India., Dey S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Organic and Medicinal Chemistry Division, Laboratory of Catalysis and Chemical Biology, Council of Scientific and Industrial Research- Indian Institute of Chemical Biology (CSIR-IICB), Jadavpur, Kolkata, 700032, India., Joshi A; Council of Scientific and Industrial Research- Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, 160036, India., Singh N; Council of Scientific and Industrial Research- Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, 160036, India., Thakur KG; Council of Scientific and Industrial Research- Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, 160036, India., Jaisankar P; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Organic and Medicinal Chemistry Division, Laboratory of Catalysis and Chemical Biology, Council of Scientific and Industrial Research- Indian Institute of Chemical Biology (CSIR-IICB), Jadavpur, Kolkata, 700032, India., Singh UP; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. umesh.singh@iicb.res.in.; Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research- Indian Institute of Chemical Biology (CSIR-IICB), Jadavpur, Kolkata, 700032, India. umesh.singh@iicb.res.in.
Source: Molecular diversity [Mol Divers] 2026 Jun; Vol. 30 (3), pp. 3949-3975. Date of Electronic Publication: 2025 Sep 07.
Publication Type: Journal Article
Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-501X
DOI:10.1007/s11030-025-11315-2