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Remodeling the sarcoma microenvironment by simultaneous targeting of urokinase-type plasminogen activator receptors and epidermal growth factor receptors to promote antitumor activity.

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Title: Remodeling the sarcoma microenvironment by simultaneous targeting of urokinase-type plasminogen activator receptors and epidermal growth factor receptors to promote antitumor activity.
Authors: Schulte AJ; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Lewellen M; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Durose W; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota., Nolan E; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota., Taghizadeh L; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota., Todhunter D; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Department of Therapeutic Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota., Bush C; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota., Lang HP; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Comparative Molecular Biosciences Graduate Program, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Center for Immunology, University of Minnesota, Minneapolis, Minnesota., Brown ME; University Imaging Center, University of Minnesota, Minneapolis, Minnesota., DePauw TA; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota., Makielski KM; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Kim JH; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Burt LE; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Overn P; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Forster CL; The University of Minnesota Biological Materials Procurement Network (BioNet), University of Minnesota, Minneapolis, Minnesota., Seelig DM; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., O'Sullivan MG; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota., Weigel BJ; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota., Murugan P; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; The University of Minnesota Biological Materials Procurement Network (BioNet), University of Minnesota, Minneapolis, Minnesota; Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minnesota., Cutter GR; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama., Lund TC; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota; Center for Immunology, University of Minnesota, Minneapolis, Minnesota; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota., Vallera DA; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Department of Therapeutic Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota., Modiano JF; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Center for Immunology, University of Minnesota, Minneapolis, Minnesota; Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minnesota; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota; Institute for Engineering in Medicine, University of Minnesota, Minneapolis, Minnesota. Electronic address: modiano@umn.edu.
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2025 Sep; Vol. 392 (9), pp. 103674. Date of Electronic Publication: 2025 Aug 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
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  Data: Remodeling the sarcoma microenvironment by simultaneous targeting of urokinase-type plasminogen activator receptors and epidermal growth factor receptors to promote antitumor activity.
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  Data: <searchLink fieldCode="AU" term="%22Schulte+AJ%22">Schulte AJ</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Lewellen+M%22">Lewellen M</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Durose+W%22">Durose W</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Nolan+E%22">Nolan E</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Taghizadeh+L%22">Taghizadeh L</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Todhunter+D%22">Todhunter D</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Department of Therapeutic Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Bush+C%22">Bush C</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.<br /><searchLink fieldCode="AU" term="%22Lang+HP%22">Lang HP</searchLink>; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Comparative Molecular Biosciences Graduate Program, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Center for Immunology, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Brown+ME%22">Brown ME</searchLink>; University Imaging Center, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22DePauw+TA%22">DePauw TA</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Makielski+KM%22">Makielski KM</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Kim+JH%22">Kim JH</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Burt+LE%22">Burt LE</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Overn+P%22">Overn P</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Forster+CL%22">Forster CL</searchLink>; The University of Minnesota Biological Materials Procurement Network (BioNet), University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Seelig+DM%22">Seelig DM</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+MG%22">O'Sullivan MG</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.<br /><searchLink fieldCode="AU" term="%22Weigel+BJ%22">Weigel BJ</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Murugan+P%22">Murugan P</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; The University of Minnesota Biological Materials Procurement Network (BioNet), University of Minnesota, Minneapolis, Minnesota; Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Cutter+GR%22">Cutter GR</searchLink>; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Lund+TC%22">Lund TC</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Division of Pediatric, Blood and Masrrow Transplantation, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota; Center for Immunology, University of Minnesota, Minneapolis, Minnesota; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Vallera+DA%22">Vallera DA</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Department of Therapeutic Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Modiano+JF%22">Modiano JF</searchLink>; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Center for Immunology, University of Minnesota, Minneapolis, Minnesota; Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minnesota; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota; Institute for Engineering in Medicine, University of Minnesota, Minneapolis, Minnesota. Electronic address: modiano@umn.edu.
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