Whole genome characterisation of DS-1-like G8P[4] rotavirus A strains circulating in South Africa between 2009 and 2021 reveals endemic sub-lineages and evidence of radical epitope changes.

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Title: Whole genome characterisation of DS-1-like G8P[4] rotavirus A strains circulating in South Africa between 2009 and 2021 reveals endemic sub-lineages and evidence of radical epitope changes.
Authors: Shange ND; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa., Mogotsi MT; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa., Ogunbayo AE; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa., Page N; National Institute for Communicable Diseases, Johannesburg, Gauteng, South Africa., Sondlane H; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa., Esona MD; Department of Virology, Sefako Makgatho Health Sciences University, Pretoria, Gauteng, South Africa., Kumwenda B; Biomedical Sciences Department, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi., Mhango C; Biomedical Sciences Department, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi; Malawi-Liverpool-Wellcome Programme, Queen Elizabeth Central Hospital Campus, Chipatala Avenue P.O. Box 30096 Chichiri, Blantyre 3, Malawi; Institute of Infection, Veterinary & Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, UK., Kawonga F; Malawi-Liverpool-Wellcome Programme, Queen Elizabeth Central Hospital Campus, Chipatala Avenue P.O. Box 30096 Chichiri, Blantyre 3, Malawi; Institute of Infection, Veterinary & Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, UK; Department of Medical Laboratory Sciences, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi., Matambo E; Biomedical Sciences Department, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi; Institute of Infection, Veterinary & Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, UK; Department of Pharmacy, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi., Mingle SNK; Department of Electron Microscopy and Histopathology, Noguchi Memorial Institute for Medical Research, University of Ghana, P. O. Box LG 581, Legon, Accra, Ghana., Dennis FE; Department of Electron Microscopy and Histopathology, Noguchi Memorial Institute for Medical Research, University of Ghana, P. O. Box LG 581, Legon, Accra, Ghana., Khuzwayo JC; Malawi-Liverpool-Wellcome Programme, Queen Elizabeth Central Hospital Campus, Chipatala Avenue P.O. Box 30096 Chichiri, Blantyre 3, Malawi; Institute of Infection, Veterinary & Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, UK; Department of Medical Laboratory Sciences, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi., Makoah NA; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa., Donato CM; Enteric Diseases Group, Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Melbourne 3052, Australia., Nyaga MM; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa. Electronic address: NyagaMM@ufs.ac.za.
Source: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2025 Oct; Vol. 134, pp. 105818. Date of Electronic Publication: 2025 Sep 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-7257 (Electronic) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE
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  Data: Whole genome characterisation of DS-1-like G8P[4] rotavirus A strains circulating in South Africa between 2009 and 2021 reveals endemic sub-lineages and evidence of radical epitope changes.
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  Data: <searchLink fieldCode="AU" term="%22Shange+ND%22">Shange ND</searchLink>; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.<br /><searchLink fieldCode="AU" term="%22Mogotsi+MT%22">Mogotsi MT</searchLink>; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.<br /><searchLink fieldCode="AU" term="%22Ogunbayo+AE%22">Ogunbayo AE</searchLink>; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.<br /><searchLink fieldCode="AU" term="%22Page+N%22">Page N</searchLink>; National Institute for Communicable Diseases, Johannesburg, Gauteng, South Africa.<br /><searchLink fieldCode="AU" term="%22Sondlane+H%22">Sondlane H</searchLink>; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.<br /><searchLink fieldCode="AU" term="%22Esona+MD%22">Esona MD</searchLink>; Department of Virology, Sefako Makgatho Health Sciences University, Pretoria, Gauteng, South Africa.<br /><searchLink fieldCode="AU" term="%22Kumwenda+B%22">Kumwenda B</searchLink>; Biomedical Sciences Department, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.<br /><searchLink fieldCode="AU" term="%22Mhango+C%22">Mhango C</searchLink>; Biomedical Sciences Department, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi; Malawi-Liverpool-Wellcome Programme, Queen Elizabeth Central Hospital Campus, Chipatala Avenue P.O. Box 30096 Chichiri, Blantyre 3, Malawi; Institute of Infection, Veterinary & Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Kawonga+F%22">Kawonga F</searchLink>; Malawi-Liverpool-Wellcome Programme, Queen Elizabeth Central Hospital Campus, Chipatala Avenue P.O. Box 30096 Chichiri, Blantyre 3, Malawi; Institute of Infection, Veterinary & Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, UK; Department of Medical Laboratory Sciences, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.<br /><searchLink fieldCode="AU" term="%22Matambo+E%22">Matambo E</searchLink>; Biomedical Sciences Department, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi; Institute of Infection, Veterinary & Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, UK; Department of Pharmacy, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.<br /><searchLink fieldCode="AU" term="%22Mingle+SNK%22">Mingle SNK</searchLink>; Department of Electron Microscopy and Histopathology, Noguchi Memorial Institute for Medical Research, University of Ghana, P. O. Box LG 581, Legon, Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Dennis+FE%22">Dennis FE</searchLink>; Department of Electron Microscopy and Histopathology, Noguchi Memorial Institute for Medical Research, University of Ghana, P. O. Box LG 581, Legon, Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Khuzwayo+JC%22">Khuzwayo JC</searchLink>; Malawi-Liverpool-Wellcome Programme, Queen Elizabeth Central Hospital Campus, Chipatala Avenue P.O. Box 30096 Chichiri, Blantyre 3, Malawi; Institute of Infection, Veterinary & Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, UK; Department of Medical Laboratory Sciences, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre 312225, Malawi.<br /><searchLink fieldCode="AU" term="%22Makoah+NA%22">Makoah NA</searchLink>; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.<br /><searchLink fieldCode="AU" term="%22Donato+CM%22">Donato CM</searchLink>; Enteric Diseases Group, Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Melbourne 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Nyaga+MM%22">Nyaga MM</searchLink>; Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa. Electronic address: NyagaMM@ufs.ac.za.
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